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CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2
Stable Identifier
R-HSA-549355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Circadian Clock (Homo sapiens)
CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)
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CRY1 and CRY2 bind the unphosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer (and by homology the BMAL1:NPAS2 (ARNTL:NPAS2) heterodimer) and prolong its half-life. The unphosphorylated BMAL1:CLOCK heterodimer only weakly activates transcription and is therefore believed to competitively reduce transcription by phosphorylated BMAL1:CLOCK heterodimer. The complex of unphosphorylated BMAL1:CLOCK with CRY may contain additional components and may traffic into the nucleus.
Participants
Input
BMAL1:CLOCK,NPAS2 [cytosol]
(Homo sapiens)
CRY1,2 [cytosol]
(Homo sapiens)
Output
BMAL1:CLOCK,NPAS2:CRY [cytosol]
(Homo sapiens)
Participates
as an event of
Circadian Clock (Homo sapiens)
Inferred From
Cry proteins stabilize unphosphorylated Bmal1:Clock,Npas2 (Mus musculus)
Authored
May, B (2010-03-19)
Reviewed
Delaunay, F (2010-06-23)
Hirota, T (2010-06-23)
Kay, SA (2010-06-23)
Albrecht, U (2010-06-23)
D'Eustachio, P (2009-05-27)
Created
May, B (2010-03-21)
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