Reactome | 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]

1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]

Stable Identifier

R-HSA-549192

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Conversion of Diacylglycerol to Triacylglycerol [DGAT2]

ReviewStatus

5/5

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1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]

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Diacylglycerol O-acyltransferase 1 (DGAT2) associated with the endoplasmic reticulum membrane catalyzes the reaction of 1,2-diacyl-glycerol and acyl-CoA to form triacylglycerol + CoASH (Cases et al. 2001, Wakimoto et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11481335	Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members Tow, B, Stone, SJ, Voelker, T, Cases, S, Lardizabal, KD, Yen, E, Farese, RV, Zhou, P	J Biol Chem	2001
14521909	A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice Okubo, K, Mitsui, H, Imai, Y, Seishima, M, Wakimoto, K, Kawasaki, S, Chiba, H, Torii, H, Michibata, H	Biochem Biophys Res Commun	2003