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Organic cation/anion/zwitterion transport
Stable Identifier
R-HSA-549132
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
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The SLC22 gene family of solute carriers function as organic cation transporters (OCTs), cation/zwitterion transporters (OCTNs) and organic anion transporters (OATs). The SLC22 family belongs to the major facilitator superfamily and comprises uniporters, symporters and antiporters.Most of this family are polyspecific transporters. Since many of these transporters are expressed in the liver, kidney and intestine, they play an important role in drug absorption and excretion. Substrates include xenobiotics, drugs, and endogenous amine compounds (Koepsell H and Endou H, 2004).
Literature References
PubMed ID
Title
Journal
Year
12883891
The SLC22 drug transporter family
Koepsell, H
,
Endou, H
Pflugers Arch
2004
Participants
Events
Organic cation transport
(Homo sapiens)
Organic anion transport
(Homo sapiens)
Participates
as an event of
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Orthologous Events
Organic cation/anion/zwitterion transport (Bos taurus)
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic cation/anion/zwitterion transport (Danio rerio)
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic cation/anion/zwitterion transport (Mus musculus)
Organic cation/anion/zwitterion transport (Plasmodium falciparum)
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Authored
Jassal, B (2010-03-17)
Reviewed
He, L (2010-05-10)
Created
Jassal, B (2010-03-17)
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