Reactome | G3P is acylated to 1-acyl LPA by AGPAT6

G3P is acylated to 1-acyl LPA by AGPAT6

Stable Identifier

R-HSA-549112

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Conversion of glycerol-3-phosphate to lysophosphatidic acid

ReviewStatus

5/5

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Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 4 (AGPAT6) at the endoplasmic reticulum (ER) membrane (Cao et al., 2006; Chen et al., 2008).

Literature References

PubMed ID	Title	Journal	Year
17170135	Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis Tobin, JF, Cao, J, Li, D, Li, JL, Gimeno, RE	Proc Natl Acad Sci U S A	2006
18238778	AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase Kuo, MS, Qian, YW, Li, S, Bredt, DS, Chu, S, Beigneux, AP, Bui, HH, Sanders, PE, Thibodeaux, SJ, Zhao, Y, Cao, G, Chen, YQ, Moller, DE, Peake, DA, Young, SG, Konrad, RJ	J Biol Chem	2008
18718904	Acyl-CoA:lysophospholipid acyltransferases Shindou, H, Shimizu, T	J Biol Chem	2009