G3P is acylated to 1-acyl LPA by AGPAT6

Stable Identifier
R-HSA-549112
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Conversion of glycerol-3-phosphate to lysophosphatidic acid
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Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 4 (AGPAT6) at the endoplasmic reticulum (ER) membrane (Cao et al., 2006; Chen et al., 2008).

Literature References
PubMed ID Title Journal Year
17170135 Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis

Tobin, JF, Cao, J, Li, D, Li, JL, Gimeno, RE

Proc Natl Acad Sci U S A 2006
18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Kuo, MS, Qian, YW, Li, S, Bredt, DS, Chu, S, Beigneux, AP, Bui, HH, Sanders, PE, Thibodeaux, SJ, Zhao, Y, Cao, G, Chen, YQ, Moller, DE, Peake, DA, Young, SG, Konrad, RJ

J Biol Chem 2008
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Participants
Participates
Catalyst Activity

glycerol-3-phosphate O-acyltransferase activity of AGPAT6 [endoplasmic reticulum membrane]

Orthologous Events
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