G3P is acylated to 1-acyl LPA by AGPAT6

Stable Identifier
R-HSA-549112
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated], Conversion of glycerol-3-phosphate to lysophosphatidic acid
Locations in the PathwayBrowser
General
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glycerol-3-phosphate (G3P) is acylated to 1-acyl lysophosphatidic acid (LPA) by the enzymes glycerol-3-phosphate acyltransferase 4 (AGPAT6) at the endoplasmic reticulum (ER) membrane (Cao et al., 2006; Chen et al., 2008).

Literature References
PubMed ID Title Journal Year
18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

Chen, YQ, Kuo, MS, Li, S, Bui, HH, Peake, DA, Sanders, PE, Thibodeaux, SJ, Chu, S, Qian, YW, Zhao, Y, Bredt, DS, Moller, DE, Konrad, RJ, Beigneux, AP, Young, SG, Cao, G

J Biol Chem 2008
17170135 Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis

Cao, J, Li, JL, Li, D, Tobin, JF, Gimeno, RE

Proc Natl Acad Sci U S A 2006
18718904 Acyl-CoA:lysophospholipid acyltransferases

Shindou, H, Shimizu, T

J Biol Chem 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glycerol-3-phosphate O-acyltransferase activity of AGPAT6 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created