Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SRI [sarcoplasmic reticulum membrane]
Stable Identifier
R-HSA-5490313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
sarcoplasmic reticulum membrane
Synonyms
Sorcin, SORCN_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Reduction of cytosolic Ca++ levels (Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Sodium/Calcium exchangers (Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)
SRI [sarcoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30626 SRI
Gene Names
SRI
Chain
chain:1-198
Reference Genes
BioGPS Gene:6717 SRI
COSMIC (genes):SRI SRI
CTD Gene:6717 SRI
dbSNP Gene:6717 SRI
ENSEMBL:ENSG00000075142 SRI
HGNC:11292 SRI
KEGG:hsa:6717 SRI
Monarch:6717 SRI
NCBI Gene:6717 SRI
OMIM:182520 SRI
UCSC:P30626 SRI
Reference Transcript
RefSeq:NM_001256892.1 SRI
RefSeq:NM_198901.1 SRI
RefSeq:NM_001256891.1 SRI
RefSeq:NM_003130.3 SRI
Other Identifiers
11739990_a_at
11739991_x_at
11744438_a_at
11744439_x_at
11747210_a_at
11758254_s_at
11760541_at
17059551
208920_PM_at
208920_at
208921_PM_s_at
208921_s_at
3060308
3060309
3060310
3060311
3060312
3060313
3060314
3060315
3060316
3060317
3060318
3060319
3060320
3060321
3060322
3060324
3060325
3060328
3060329
3060330
3060331
39055_at
50405_at
6717
8140828
A_23_P358928
A_23_P59718
GE56518
GE79858
GO:0001508
GO:0002020
GO:0005102
GO:0005246
GO:0005509
GO:0005515
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006816
GO:0006880
GO:0006942
GO:0007165
GO:0007507
GO:0007517
GO:0008016
GO:0010459
GO:0010649
GO:0010880
GO:0016020
GO:0016529
GO:0030018
GO:0030315
GO:0031982
GO:0033017
GO:0035774
GO:0042584
GO:0042802
GO:0043226
GO:0044325
GO:0046872
GO:0046982
GO:0048856
GO:0051281
GO:0051924
GO:0055118
GO:0060315
GO:0070062
GO:0086004
GO:0098772
GO:0140297
GO:1901077
GO:1901841
GO:1901844
HMNXSV003036536
Hs.300741.0.S2_3p_at
Hs.300741.0.S2_3p_x_at
ILMN_1682054
ILMN_1696119
ILMN_1699525
ILMN_2400219
M32886_at
PH_hs_0028390
TC07001581.hg
g459835_3p_a_at
This entity regulates
Positively
ATP2A1-3 transport Ca2+ from cytosol to ER lumen
(Homo sapiens)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol
(Homo sapiens)
SLC8A1,2,3 exchange 3Na+ for Ca2+
(Homo sapiens)
Inferred To
SRI [sarcoplasmic reticulum membrane]
(Bos taurus)
SRI [sarcoplasmic reticulum membrane]
(Canis familiaris)
SRI [sarcoplasmic reticulum membrane]
(Gallus gallus)
SRI [sarcoplasmic reticulum membrane]
(Mus musculus)
SRI [sarcoplasmic reticulum membrane]
(Sus scrofa)
Sri [sarcoplasmic reticulum membrane]
(Rattus norvegicus)
sri [sarcoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000265729
,
ENSP00000378137
,
ENSP00000391148
,
ENST00000431660
,
ENST00000394641
,
ENSP00000265729
OpenTargets
ENSG00000075142
HPA
ENSG00000075142-SRI
PRO
P30626
Pharos - Targets
P30626
GlyGen
P30626
HMDB Protein
HMDBP08003
PDB
4USL
,
5MRA
,
2JC2
,
4UPG
,
1JUO
,
4U8D
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13137 CACO2
0.742
5
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.635
3
UniProt:Q08493-3 PDE4C
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q08493-2 PDE4C
0.556
3
UniProt:Q99081 TCF12
1
TCF12 [nucleoplasm]
(R-HSA-445670)
0.556
3
UniProt:Q9NZ81 PRR13
0.556
3
UniProt:P30626 SRI
1
SRI [sarcoplasmic reticulum membrane]
(R-HSA-5490313)
0.553
2
UniProt:P49810 PSEN2
2
PSEN2(298-448) [plasma membrane]
(R-HSA-9013329)
PSEN2(1-297) [plasma membrane]
(R-HSA-201599)
0.544
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text