ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA

Stable Identifier
R-HSA-548815
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
arachidoyl-CoA + malonyl-CoA => 3-oxobehenoyl-CoA + CO2 + CoASH [ELOVL7]
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Elongation of very long chain fatty acids protein 7 (ELOVL7) catalyzes the reaction of arachidoyl-CoA (C20:0) and malonyl-CoA to form 3-oxobehenoyl-CoA, CO2, and CoASH. ELOVL7 is localized to the endoplasmic reticulum in transfected cells expressing the cloned cDNA (Tamura et al. 2009).

Literature References
PubMed ID Title Journal Year
19826053 Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism

Tamura, K, Makino, A, Hullin-Matsuda, F, Kobayashi, T, Furihata, M, Chung, S, Ashida, S, Miki, T, Fujioka, T, Shuin, T, Nakamura, Y, Nakagawa, H

Cancer Res 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid elongase activity of ELOVL7 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!