ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

Stable Identifier
R-HSA-548800
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH
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Elongation of very long chain fatty acids proteins 1, 2, 3 and 5 (ELOVL1,2,3,5) catalyse the elongation of arachidonyl-CoA (AA-CoA) and malonyl-CoA (Mal-CoA) to form 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA (3ODCT-CoA) (Leonard et al. 2002, Ohno et al. 2010).

Literature References
PubMed ID Title Journal Year
20937905 ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Ohno, Y, Suto, S, Yamanaka, M, Mizutani, Y, Mitsutake, S, Igarashi, Y, Sassa, T, Kihara, A

Proc Natl Acad Sci U S A 2010
12371743 Identification and expression of mammalian long-chain PUFA elongation enzymes

Leonard, AE, Kelder, B, Bobik, EG, Chuang, LT, Lewis, CJ, Kopchick, JJ, Mukerji, P, Huang, YS

Lipids 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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