Reactome | ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

Stable Identifier

R-HSA-548800

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA, arachidonoyl-CoA + malonyl-CoA => 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA + CO2 + CoASH

ReviewStatus

5/5

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ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

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Elongation of very long chain fatty acids proteins 1, 2, 3 and 5 (ELOVL1,2,3,5) catalyse the elongation of arachidonyl-CoA (AA-CoA) and malonyl-CoA (Mal-CoA) to form 3-oxo-(7,10,13,16)-docosatetraenoyl-CoA (3ODCT-CoA) (Leonard et al. 2002, Ohno et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
12371743	Identification and expression of mammalian long-chain PUFA elongation enzymes Lewis, CJ, Huang, YS, Kopchick, JJ, Bobik, EG, Kelder, B, Chuang, LT, Mukerji, P, Leonard, AE	Lipids	2002
20937905	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis Suto, S, Sassa, T, Yamanaka, M, Igarashi, Y, Ohno, Y, Kihara, A, Mizutani, Y, Mitsutake, S	Proc Natl Acad Sci U S A	2010