Hh processing variants are ubiquitinated

Stable Identifier
R-HSA-5483238
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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Hh processing variants are ubiquitinated
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Processing-defective SHH variants are ubiquitinated by SYVN1 (Chen et al, 2011).
Literature References
PubMed ID Title Journal Year
21357747 Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

Chen, X, Tukachinsky, H, Huang, CH, Jao, C, Chu, YR, Tang, HY, Mueller, B, Schulman, S, Rapoport, TA, Salic, A

J. Cell Biol. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]

Physical Entity
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Functional status

Gain of function of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
holoprosencephaly DOID:4621 Holoprosencephaly sequence (disorder)
Cross References
Mondo
Authored
Rothfels, K  (2014-05-16)
Reviewed
Liu, Y C  (2014-05-16)
Created
Rothfels, K  (2014-05-16)
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