GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG

Stable Identifier
R-HSA-5433072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
To be excreted in urine, glutathione conjugates undergo several hydrolysis steps to form mercapturic acids which are readily excreted. The first step is the hydrolysis of a gamma-glutamyl residue from the conjugate catalysed by gamma-glutamyltransferases (GGTs). These are membrane-bound, heterodimeric enzymes composed of light and heavy peptide chains. GGT1 and 2 are well characterised while GGT3P, 5, 6 and 7 are putative transferases. Extracellular glutathione or its conjugates can be hydrolysed to give cysteinylglycine (CG, or CG conjugates) and free glutamate (L-Glu) (Heisterkamp et al. 2008, Tate & Ross 1977, Pawlak et al. 1989).
Literature References
PubMed ID Title Journal Year
18357469 The human gamma-glutamyltransferase gene family

Groffen, J, Sneddon, TP, Heisterkamp, N, Warburton, D

Hum Genet 2008
2573352 Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney

Ferry, N, Bulle, F, Pawlak, A, Wu, SJ, Chikhi, N, Baik, JH, Guellaƫn, G, Suzuki, A, Siegrist, S

Biochem Biophys Res Commun 1989
19463 Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit

Ross, ME, Tate, SS

J Biol Chem 1977
Participants
Participates
Catalyst Activity

glutathione hydrolase activity of GGT dimers [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!