GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG

Stable Identifier
Reaction [transition]
Homo sapiens
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To be excreted in urine, glutathione conjugates undergo several hydrolysis steps to form mercapturic acids which are readily excreted. The first step is the hydrolysis of a gamma-glutamyl residue from the conjugate catalysed by gamma-glutamyltransferases (GGTs). These are membrane-bound, heterodimeric enzymes composed of light and heavy peptide chains. GGT1 and 2 are well characterised while GGT3P, 5, 6 and 7 are putative transferases. Extracellular glutathione or its conjugates can be hydrolysed to give cysteinylglycine (CG, or CG conjugates) and free glutamate (L-Glu) (Heisterkamp et al. 2008, Tate & Ross 1977, Pawlak et al. 1989).
Literature References
PubMed ID Title Journal Year
18357469 The human gamma-glutamyltransferase gene family

Groffen, J, Sneddon, TP, Heisterkamp, N, Warburton, D

Hum Genet 2008
2573352 Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney

Ferry, N, Bulle, F, Pawlak, A, Wu, SJ, Chikhi, N, Baik, JH, Guellaƫn, G, Suzuki, A, Siegrist, S

Biochem Biophys Res Commun 1989
19463 Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit

Ross, ME, Tate, SS

J Biol Chem 1977
Catalyst Activity

glutathione hydrolase activity of GGT dimers [plasma membrane]

Orthologous Events
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