Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C

Stable Identifier
R-HSA-5433066
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
Synonyms
acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)
ReviewStatus
5/5
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Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C
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An unknown cysteine-S-conjugate N-acetyltransferase (NAT) catalyses the transfer of an acetyl group from acetyl CoA (Ac-CoA) to the exo and endo forms of aflatoxin B1-cysteinyl conjugates (AFXBO-C, AFNBO-C). The resultant N-acetylcysteine-S-conjugate is termed a mercapturic acid which is readily excreted in urine (Hinchman & Ballatori 1994).
Literature References
PubMed ID Title Journal Year
8145281 Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process

Hinchman, CA, Ballatori, N

J Toxicol Environ Health 1994
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Output
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as an event of
Catalyst Activity

L-cysteine-S-conjugate N-acetyltransferase activity of unknown NAT [cytosol]

Physical Entity
unknown NAT [cytosol] (Homo sapiens)
Activity
L-cysteine-S-conjugate N-acetyltransferase activity (GO:0047198)
Cross References
RHEA
Authored
Jassal, B  (2014-05-12)
Reviewed
D'Eustachio, P  (2014-05-22)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2014-05-12)
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