AFXBO hydrolyses non-enzymatically to AFBDHD

Stable Identifier
R-HSA-5423656
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AFXBO hydrolyses non-enzymatically to AFBDHD
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The exo- and endo-epoxides of aflatoxin B1 are unstable in water and can undergo rapid non-enzymatic hydrolysis to AFB1-8,9-dihydrodiol (AFBDHD) (Johnson et al. 1997, Guengerich et al. 1998).
Literature References
PubMed ID Title Journal Year
9208174 Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase

Johnson, WW, Yamazaki, H, Shimada, T, Ueng, YF, Guengerich, FP

Chem. Res. Toxicol. 1997
9675258 Activation and detoxication of aflatoxin B1

Guengerich, FP, Johnson, WW, Shimada, T, Ueng, YF, Yamazaki, H, Langouët, S

Mutat. Res. 1998
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Authored
Jassal, B  (2014-05-09)
Reviewed
D'Eustachio, P  (2014-05-22)
Created
Jassal, B  (2014-05-09)
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