AFXBO hydrolyses non-enzymatically to AFBDHD

Stable Identifier
R-HSA-5423656
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AFXBO hydrolyses non-enzymatically to AFBDHD
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The exo- and endo-epoxides of aflatoxin B1 are unstable in water and can undergo rapid non-enzymatic hydrolysis to AFB1-8,9-dihydrodiol (AFBDHD) (Johnson et al. 1997, Guengerich et al. 1998).

Literature References
PubMed ID Title Journal Year
9208174 Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase

Guengerich, FP, Johnson, WW, Yamazaki, H, Ueng, YF, Shimada, T

Chem. Res. Toxicol. 1997
9675258 Activation and detoxication of aflatoxin B1

Johnson, WW, Guengerich, FP, Yamazaki, H, Ueng, YF, Langouët, S, Shimada, T

Mutat. Res. 1998
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Authored
Jassal, B  (2014-05-09)
Reviewed
D'Eustachio, P  (2014-05-22)
Created
Jassal, B  (2014-05-09)
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