AFXBO binds DNA

Stable Identifier
R-HSA-5423632
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AFXBO binds DNA
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Aflatoxin B1 (AFB1), a category I known human carcinogen and the most potent genotoxic agent, is mutagenic in many model systems. Aflatoxin B1 exo-8,9-epoxide (AFXBO) binds to DNA to form the predominant 8,9-dihydro-8-(N7 guanyl)-9-hydroxy-AFB1 (AFB1-N7-Gua) adduct. AFB1-N7-Gua confers the mutagenic properties of the compound (Raney et al. 1993, Bedard & Massey 2006).
Literature References
PubMed ID Title Journal Year
8448352 DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin B1 8,9-exo-epoxide

Raney, VM, Stone, MP, Harris, TM

Chem. Res. Toxicol. 1993
16458422 Aflatoxin B1-induced DNA damage and its repair

Bedard, LL, Massey, TE

Cancer Lett. 2006
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Disease
Name Identifier Synonyms
hepatocellular carcinoma DOID:684 adult Hepatoma, adult primary Liver carcinoma, Liver carcinoma, Hepatocellular carcinoma (morphologic abnormality), primary carcinoma of liver (disorder), hepatoma, Hepatoma, adult primary hepatocellular carcinoma, primary carcinoma of the liver cells, Hepatocellular carcinoma (clinical), Liver carcinoma, HCC, carcinoma of liver, specified as primary
Authored
Jassal, B  (2014-05-09)
Reviewed
D'Eustachio, P  (2014-05-22)
Created
Jassal, B  (2014-05-09)
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