Reactome | PHF8 [nucleoplasm]

PHF8 [nucleoplasm]

Stable Identifier

R-HSA-5423096

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone lysine demethylase PHF8, PHF8_HUMAN, JHDM1E

Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1

Expand all

External Reference Information

External Reference

UniProt:Q9UPP1 PHF8

Gene Names

PHF8, KIAA1111, ZNF422

Chain

chain:1-1060

Reference Genes

BioGPS Gene:23133 PHF8

COSMIC (genes):PHF8 PHF8

CTD Gene:23133 PHF8

dbSNP Gene:23133 PHF8

ENSEMBL:ENSG00000172943 PHF8

ENSEMBL_homo_sapiens_GENE:ENSG00000172943.21 PHF8

HGNC:20672 PHF8

KEGG Gene (Homo sapiens):23133 PHF8

Monarch:23133 PHF8

NCBI Gene:23133 PHF8

OMIM:300560 PHF8

UCSC:Q9UPP1 PHF8

Reference Transcript

Other Identifiers

11719423_at

11756084_a_at

17111366

212916_PM_at

212916_at

23133

4009503

4009505

4009507

4009508

4009509

4009510

4009511

4009512

4009513

4009516

4009521

4009522

4009524

4009526

4009527

4009528

4009530

4009531

4009532

4009534

4009536

4009538

4009539

4009540

4009542

4009543

4009544

4009545

4009546

4009547

4009549

4009550

4009552

4009553

4009554

4009555

41399_at

8173009

A_23_P9744

A_24_P130865

A_24_P942253

A_33_P3361925

GO:0000082

GO:0000278

GO:0003682

GO:0003712

GO:0003824

GO:0005506

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005730

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0007049

GO:0007420

GO:0008270

GO:0016491

GO:0016706

GO:0031965

GO:0032452

GO:0032454

GO:0035064

GO:0035575

GO:0036211

GO:0042393

GO:0043226

GO:0045893

GO:0045943

GO:0045944

GO:0046872

GO:0048856

GO:0051213

GO:0051864

GO:0061188

GO:0071558

GO:0140096

GO:0140110

GO:0140680

GO:0140683

GO:0141052

HMNXSV003015923

HMNXSV003018229

HMNXSV003026449

Hs.285641.0.S1_3p_at

ILMN_1711318

ILMN_2230530

PH_hs_0022505

TC0X001070.hg

Participates

as a member of

KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8 [nucleoplasm] (Homo sapiens)

Inferred To

Phf8 [nucleoplasm] (Rattus norvegicus)

PHF8-1 [nucleoplasm] (Caenorhabditis elegans)

PHF8-1 [nucleoplasm] (Danio rerio)

PHF8-1 [nucleoplasm] (Schizosaccharomyces pombe)

PHF8 [nucleoplasm] (Bos taurus)

PHF8 [nucleoplasm] (Canis familiaris)

PHF8 [nucleoplasm] (Mus musculus)

PHF8 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001171826.1, NP_055922.1, XP_016884851.1, NP_001171825.1

Guide to Pharmacology - Targets

2698

OpenTargets

ENSG00000172943

ZINC - Substances

PHF8_HUMAN

ZINC target

Q9UPP1

ZINC - Biogenic

PHF8_HUMAN

PRO

Q9UPP1

PDB

4DO0, 7CMZ, 3KV4, 3K3O, 2WWU, 3K3N

ZINC - Metabolites

PHF8_HUMAN

GeneCards

Q9UPP1

HPA

ENSG00000172943-PHF8

Ensembl

ENST00000322659, ENSP00000350676, ENSP00000338868, ENST00000357988, ENSP00000319473, ENSG00000172943, ENST00000338154

Pharos - Targets

Q9UPP1

ZINC - Predictions - Purchasable

PHF8_HUMAN

Orphanet

16818

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y462 ZNF711	1	ZNF711 [nucleoplasm] (R-HSA-2454159)	0.69	7
UniProt:Q16778 H2BC21	9	Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) HIST2H2BE [extracellular region] (R-HSA-977571) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) HIST2H2BE [nucleoplasm] (R-HSA-181908)	0.527	2
UniProt:Q96QS3 ARX			0.524	3
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.499	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.499	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	7

Cite Us!