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KDM1B [nucleoplasm]
Stable Identifier
R-HSA-5423072
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific histone demethylase 1B ecNumber1.-.-.-/ecNumber, KDM1B_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM1A, KDM1B demethylate Me2K5-histone H3 (Homo sapiens)
KDM1A,KDM1B [nucleoplasm] (Homo sapiens)
KDM1B [nucleoplasm] (Homo sapiens)
KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)
KDM1A,KDM1B [nucleoplasm] (Homo sapiens)
KDM1B [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)
PR-DUB complex [nucleoplasm] (Homo sapiens)
KDM1B [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)
ABCG1 gene:NR1H2,3:RXR:oxysterol:GPS2:KDMs [nucleoplasm] (Homo sapiens)
KDM1A, KDM1B, KDM3A, KDM4A [nucleoplasm] (Homo sapiens)
KDM1B [nucleoplasm] (Homo sapiens)
Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)
ABCG1 gene:NR1H2,3:RXR:oxysterol:GPS2:KDMs [nucleoplasm] (Homo sapiens)
KDM1A, KDM1B, KDM3A, KDM4A [nucleoplasm] (Homo sapiens)
KDM1B [nucleoplasm] (Homo sapiens)
KDM1A, KDM1B, KDM3A, KDM4A [nucleoplasm] (Homo sapiens)
KDM1B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NB78 KDM1B
Gene Names
KDM1B, AOF1, C6orf193, LSD2
Chain
chain:1-822
Reference Genes
BioGPS Gene:221656 KDM1B
COSMIC (genes):KDM1B KDM1B
CTD Gene:221656 KDM1B
dbSNP Gene:221656 KDM1B
ENSEMBL:ENSG00000165097 KDM1B
HGNC:21577 KDM1B
Monarch:221656 KDM1B
NCBI Gene:221656 KDM1B
OMIM:613081 KDM1B
UCSC:Q8NB78 KDM1B
Reference Transcript
RefSeq:XM_005248926.1 KDM1B
RefSeq:NM_153042.3 KDM1B
Other Identifiers
11719912_a_at
11751862_a_at
1553150_PM_at
1553150_at
17005169
221656
227021_PM_at
227021_at
2897110
2897112
2897113
2897115
2897117
2897118
2897120
2897122
2897125
2897127
2897128
2897129
2897130
2897131
2897132
2897134
2897135
2897137
2897139
2897140
2897142
2897143
2897144
2897145
2897146
2897148
2897150
2897151
2897152
2897153
2897154
2897155
2897156
2897157
2897158
2897159
61273_s_at
62487_i_at
77891_at
8117081
A_14_P110238
A_14_P112699
A_14_P133581
A_23_P338401
GE88023
GO:0000786
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006338
GO:0008270
GO:0016491
GO:0032452
GO:0032453
GO:0042393
GO:0043226
GO:0044726
GO:0046872
GO:0050660
GO:0071514
GO:0071949
GO:0140096
GO:0140682
HMNXSV003002105
HMNXSV003008121
Hs.237691.0.A1_3p_at
ILMN_1781537
PH_hs_0012866
TC06000117.hg
Participates
as a member of
KDM1A, KDM1B, KDM3A, KDM4A [nucleoplasm] (Homo sapiens)
KDM1A,KDM1B [nucleoplasm] (Homo sapiens)
as a component of
PR-DUB complex [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of KDM1B [nucleoplasm]
(Drosophila melanogaster)
Kdm1b [nucleoplasm]
(Rattus norvegicus)
FMS1 [nucleoplasm]
(Saccharomyces cerevisiae)
KDM1B [nucleoplasm]
(Bos taurus)
KDM1B [nucleoplasm]
(Caenorhabditis elegans)
KDM1B [nucleoplasm]
(Canis familiaris)
KDM1B [nucleoplasm]
(Gallus gallus)
KDM1B [nucleoplasm]
(Mus musculus)
KDM1B [nucleoplasm]
(Schizosaccharomyces pombe)
KDM1B [nucleoplasm]
(Sus scrofa)
kdm1b [nucleoplasm]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2670
ENSEMBL
ENST00000650836
,
ENSP00000297792
,
ENSP00000499208
OpenTargets
ENSG00000165097
HPA
ENSG00000165097-KDM1B
ZINC - Substances
KDM1B_HUMAN
ZINC target
Q8NB78
PRO
Q8NB78
Pharos - Targets
Q8NB78
GlyGen
Q8NB78
HMDB Protein
HMDBP08264
PDB
4HSU
,
7XE3
,
4GUT
,
4GU0
,
4GUU
,
7XE1
,
4GU1
,
4GUR
,
4FWJ
,
7XE2
,
4GUS
,
4FWF
,
6R1U
,
4FWE
,
6R25
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92560 BAP1
1
BAP1 [nucleoplasm]
(R-HSA-5689665)
0.643
4
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
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