Reactome | SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)

SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)

Stable Identifier

R-HSA-5423038

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SETD8 methylates lysine-21 of histone H4

ReviewStatus

5/5

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SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)

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Monomethylation of lysine-21 of histone H4 (H4K20) is performed by SETD8 (KMT5A) (Yin et al. 2005). Trimethylation, performed by SUV420H1 and SUV420H2 and possibly SMYD3 (Foreman et al. 2011), is associated with heterochromatin formation and gene repression (Schotta et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
21779408	Structural and functional profiling of the human histone methyltransferase SMYD3 Foreman, KW, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P	PLoS ONE	2011
15964846	SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20 Yin, Y, Liu, C, Tsai, SN, Zhou, B, Ngai, SM, Zhu, G	J. Biol. Chem.	2005