Reactome | Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)

Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)

Stable Identifier

R-HSA-5419279

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

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Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)

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GFM1 (EF-Gmt, EF-G1mt) of the GFM1:GTP complex hydrolyzes GTP, yielding GFM1:GDP (Tsuboi et al. 2009). The hydrolysis of GTP drives translocation of the peptidyl-tRNA from the A-site to the P-site with consequent ejection of the deacylated tRNA from the P-site and translocation of the ribosome in the 3' direction along the mRNA (Bhargava et al. 2004, Tsuboi et al. 2009, inferred from bovine homologs in Chung and Spremulli 1990).

Literature References

PubMed ID	Title	Journal	Year
15358359	Expression and characterization of isoform 1 of human mitochondrial elongation factor G Bhargava, K, Templeton, P, Spremulli, LL	Protein Expr. Purif.	2004
19716793	EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis Tsuboi, M, Morita, H, Nozaki, Y, Akama, K, Ueda, T, Ito, K, Nierhaus, KH, Takeuchi, N	Mol. Cell	2009