Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
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GFM1 (EF-Gmt, EF-G1mt) of the GFM1:GTP complex hydrolyzes GTP, yielding GFM1:GDP (Tsuboi et al. 2009). The hydrolysis of GTP drives translocation of the peptidyl-tRNA from the A-site to the P-site with consequent ejection of the deacylated tRNA from the P-site and translocation of the ribosome in the 3' direction along the mRNA (Bhargava et al. 2004, Tsuboi et al. 2009, inferred from bovine homologs in Chung and Spremulli 1990).

Literature References
PubMed ID Title Journal Year
15358359 Expression and characterization of isoform 1 of human mitochondrial elongation factor G

Spremulli, LL, Templeton, P, Bhargava, K

Protein Expr. Purif. 2004
19716793 EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis

Tsuboi, M, Nierhaus, KH, Ito, K, Nozaki, Y, Takeuchi, N, Akama, K, Morita, H, Ueda, T

Mol. Cell 2009
Catalyst Activity

GTPase activity of 55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane]

Inferred From
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