Hydrolysis of GTP and dissociation of 28S and 39S subunits

Stable Identifier
R-HSA-5419273
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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When complexed with ribosomes GFM2 (EF-G2mt) hydrolyzes GTP and, together with MRRF, acts as a ribosome releasing factor by splitting 55S ribosomes into 28S and 39S subunits (Tsuboi et al. 2009). Though GTP is hydrolyzed during the reaction, hydrolysis is not necessary for splitting the 55S ribosome into 39S and 28S subunits, but is necessary for dissociation of GFM2 (as GFM2:GDP) and MRRF from the large ribosomal subunit after splitting (Tsuboi et al. 2009).

Literature References
PubMed ID Title Journal Year
19716793 EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis

Tsuboi, M, Morita, H, Nozaki, Y, Akama, K, Ueda, T, Ito, K, Nierhaus, KH, Takeuchi, N

Mol. Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of 55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created