Reactome | Hydrolysis of GTP and dissociation of 28S and 39S subunits

Hydrolysis of GTP and dissociation of 28S and 39S subunits

Stable Identifier

R-HSA-5419273

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

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Hydrolysis of GTP and dissociation of 28S and 39S subunits

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When complexed with ribosomes GFM2 (EF-G2mt) hydrolyzes GTP and, together with MRRF, acts as a ribosome releasing factor by splitting 55S ribosomes into 28S and 39S subunits (Tsuboi et al. 2009). Though GTP is hydrolyzed during the reaction, hydrolysis is not necessary for splitting the 55S ribosome into 39S and 28S subunits, but is necessary for dissociation of GFM2 (as GFM2:GDP) and MRRF from the large ribosomal subunit after splitting (Tsuboi et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19716793	EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis Tsuboi, M, Morita, H, Nozaki, Y, Akama, K, Ueda, T, Ito, K, Nierhaus, KH, Takeuchi, N	Mol. Cell	2009