Reactome | 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP

55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP

Stable Identifier

R-HSA-5419261

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

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55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP

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GFMT1:GTP (EF-G1mt:GTP) binds ribosomes possessing a peptidyl-tRNA at the A site and an empty P site (Bhargava et al. 2004, Tsuboi et al. 2009, inferred from bovine homologs in Chung and Spremulli 1990).

Literature References

PubMed ID	Title	Journal	Year
2250005	Purification and characterization of elongation factor G from bovine liver mitochondria Chung, HK, Spremulli, LL	J. Biol. Chem.	1990
15358359	Expression and characterization of isoform 1 of human mitochondrial elongation factor G Bhargava, K, Templeton, P, Spremulli, LL	Protein Expr. Purif.	2004
19716793	EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis Tsuboi, M, Morita, H, Nozaki, Y, Akama, K, Ueda, T, Ito, K, Nierhaus, KH, Takeuchi, N	Mol. Cell	2009