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28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA
Stable Identifier
R-HSA-5389849
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial matrix
,
mitochondrial inner membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)
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As inferred from bovine homologs, the 28S ribosomal subunit in a complex with MTIF3 (IF-3Mt, IF3mt) binds mRNA and, at some point, MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP). If an initiation codon is present at the 5' end of the mRNA then MTIF2:GTP assists the binding of N-formylmethionyl-tRNA and a stable, productive initiation complex results. If no initiation codon is present, the mRNA slides through the 28S subunit and then dissociates.
Participants
Input
28S ribosomal subunit:MTIF3 [mitochondrial inner membrane]
(Homo sapiens)
fMet-tRNA(fMet) [mitochondrial matrix]
(Homo sapiens)
mRNA [mitochondrial matrix]
MTIF2:GTP [mitochondrial matrix]
(Homo sapiens)
Output
28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA [mitochondrial inner membrane]
(Homo sapiens)
Participates
as an event of
Mitochondrial translation initiation (Homo sapiens)
Inferred From
28S subunit binds MITF2:GTP, mRNA, and formylMet-tRNA (Bos taurus)
Authored
May, B (2014-04-26)
Reviewed
Chrzanowska-Lightowlers, ZM (2014-08-29)
Spremulli, LL (2014-09-20)
Created
May, B (2014-04-30)
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