processing defective Hh variants are degraded by the proteasome

Stable Identifier
R-HSA-5387392
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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processing defective Hh variants are degraded by the proteasome
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After retrotranslocation to the cytosol, processing-defective Hh variants are degraded by the proteasome (Chen et al, 2011; Huang et al, 2013).

Literature References
PubMed ID Title Journal Year
21357747 Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

Jao, C, Rapoport, TA, Tang, HY, Chu, YR, Schulman, S, Huang, CH, Chen, X, Salic, A, Mueller, B, Tukachinsky, H

J. Cell Biol. 2011
23867461 Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum

Ye, Y, Chu, YR, Hsiao, HT, Huang, CH, Chen, X

J. Biol. Chem. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Functional status

Gain of function of ub-SHH variants [cytosol]

Disease Entity
Status
Disease
Name Identifier Synonyms
holoprosencephaly DOID:4621 Holoprosencephaly sequence (disorder)
Authored
Rothfels, K  (2014-03-29)
Reviewed
Liu, Y C  (2014-05-16)
Created
Rothfels, K  (2014-04-30)
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