As is the case for the WT Hh C-terminal fragment, siRNA depletion of SEL1 and SYVN1 inhibits the degradation of processing-defective Hh mutants, suggesting these versions of Hh are also targets for ERAD-mediated degradation (Chen et al, 2011; Huang et al, 2013).
Huang, CH, Hsiao, HT, Chu, YR, Ye, Y, Chen, X
Chen, X, Tukachinsky, H, Huang, CH, Jao, C, Chu, YR, Tang, HY, Mueller, B, Schulman, S, Rapoport, TA, Salic, A
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