As is the case for the WT Hh C-terminal fragment, siRNA depletion of SEL1 and SYVN1 inhibits the degradation of processing-defective Hh mutants, suggesting these versions of Hh are also targets for ERAD-mediated degradation (Chen et al, 2011; Huang et al, 2013).
Jao, C, Rapoport, TA, Tang, HY, Chu, YR, Schulman, S, Huang, CH, Chen, X, Salic, A, Mueller, B, Tukachinsky, H
Ye, Y, Chu, YR, Hsiao, HT, Huang, CH, Chen, X
Gain of function of SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen]
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