After stimulation by WNT3A, FZD5 and phosphorylated LRP6 are internalized from lipid rafts in a caveolin- and RAB5-dependent manner (Yamamoto et al, 2006; Yamamoto et al, 2008). Recruitment of CAV1 to the activated receptor complex inhibits the binding of beta-catenin to AXIN in the destruction complex, resulting in the accumulation of cytosolic beta-catenin and the induction of WNT-dependent signaling (Yamamoto et al, 2006; Yamamoto et al, 2008).
Kikuchi, A, Michiue, T, Yamamoto, H, Yamamoto, H, Sakane, H
Kikuchi, A, Komekado, H, Yamamoto, H
© 2023 Reactome
