WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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After stimulation by WNT3A, FZD5 and phosphorylated LRP6 are internalized from lipid rafts in a caveolin- and RAB5-dependent manner (Yamamoto et al, 2006; Yamamoto et al, 2008). Recruitment of CAV1 to the activated receptor complex inhibits the binding of beta-catenin to AXIN in the destruction complex, resulting in the accumulation of cytosolic beta-catenin and the induction of WNT-dependent signaling (Yamamoto et al, 2006; Yamamoto et al, 2008).

Literature References
PubMed ID Title Journal Year
18606139 Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling

Kikuchi, A, Michiue, T, Yamamoto, H, Yamamoto, H, Sakane, H

Dev. Cell 2008
16890161 Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

Kikuchi, A, Komekado, H, Yamamoto, H

Dev. Cell 2006
Orthologous Events
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