CCDC88C was identified as Dapple in a screen of mouse brain cDNAs for DVL1-interacting proteins (Oshita et al, 2003). CCDC88C binds to the PDZ domain of DVL through the three amino acids Gly-Cys-Val at the C-terminus, and this interaction negatively regulates canonical WNT signaling (Oshita et al, 2003; Ekici et al, 2010). Interaction between DVL and CCDC88C also regulates signaling in the non-canonical WNT pathway, where the interaction is required for aPKC-mediated RAC activation, lamellipodia formation and cell migration (Ishida-Takagisha et al, 2012).
Ekici, AB, Hilfinger, D, Jatzwauk, M, Thiel, CT, Wenzel, D, Lorenz, I, Boltshauser, E, Goecke, TW, Staatz, G, Morris-Rosendahl, DJ, Sticht, H, Hehr, U, Reis, A, Rauch, A
Oshita, A, Kishida, S, Kobayashi, H, Michiue, T, Asahara, T, Asashima, M, Kikuchi, A
Ishida-Takagishi, M, Enomoto, A, Asai, N, Ushida, K, Watanabe, T, Hashimoto, T, Kato, T, Weng, L, Matsumoto, S, Asai, M, Murakumo, Y, Kaibuchi, K, Kikuchi, A, Takahashi, M
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