CCDC88C was identified as Dapple in a screen of mouse brain cDNAs for DVL1-interacting proteins (Oshita et al, 2003). CCDC88C binds to the PDZ domain of DVL through the three amino acids Gly-Cys-Val at the C-terminus, and this interaction negatively regulates canonical WNT signaling (Oshita et al, 2003; Ekici et al, 2010). Interaction between DVL and CCDC88C also regulates signaling in the non-canonical WNT pathway, where the interaction is required for aPKC-mediated RAC activation, lamellipodia formation and cell migration (Ishida-Takagisha et al, 2012).
Kikuchi, A, Asashima, M, Michiue, T, Kishida, S, Asahara, T, Oshita, A, Kobayashi, H
Ekici, AB, Morris-Rosendahl, DJ, Wenzel, D, Boltshauser, E, Lorenz, I, Thiel, CT, Jatzwauk, M, Staatz, G, Sticht, H, Hilfinger, D, Hehr, U, Reis, A, Goecke, TW, Rauch, A
Murakumo, Y, Kikuchi, A, Weng, L, Asai, N, Asai, M, Watanabe, T, Ushida, K, Enomoto, A, Kato, T, Kaibuchi, K, Matsumoto, S, Ishida-Takagishi, M, Takahashi, M, Hashimoto, T
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