Binding of DKK1 to LRP6 induces the clathrin-mediated endocytosis of LRP6, preventing the WNT3-dependent phosphorylation of LRP and thereby attenuating WNT signaling (Sakane et al, 2010; Yamamoto et al, 2008). The DKK:LRP:KRM complex traffics to the early endosome in a RAB5-dependent manner. The LRP receptor can subsequently recycle back to the plasma membrane in a RAB11-dependent manner, while DKK may be degraded in the lysosome (Sakane et al, 2010)
Yamamoto, H, Yamamoto, H, Sakane, H, Michiue, T, Kikuchi, A
Sakane, H, Yamamoto, H, Kikuchi, A
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