Reactome | DKK promotes clathrin-dependent internalization of LRP6

DKK promotes clathrin-dependent internalization of LRP6

Stable Identifier

R-HSA-5368586

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, early endosome membrane

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DKK promotes clathrin-dependent internalization of LRP6

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Binding of DKK1 to LRP6 induces the clathrin-mediated endocytosis of LRP6, preventing the WNT3-dependent phosphorylation of LRP and thereby attenuating WNT signaling (Sakane et al, 2010; Yamamoto et al, 2008). The DKK:LRP:KRM complex traffics to the early endosome in a RAB5-dependent manner. The LRP receptor can subsequently recycle back to the plasma membrane in a RAB11-dependent manner, while DKK may be degraded in the lysosome (Sakane et al, 2010)

Literature References

PubMed ID	Title	Journal	Year
18606139	Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling Yamamoto, H, Yamamoto, H, Sakane, H, Michiue, T, Kikuchi, A	Dev. Cell	2008
20053636	LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse Sakane, H, Yamamoto, H, Kikuchi, A	J. Cell. Sci.	2010