CXXC4 binds DVL to prevent AXIN binding

Stable Identifier
R-HSA-5368582
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CXXC4 binds to DVL to negatively regulate WNT-dependent gene expression. CXXC4 competes with AXIN for DVL binding, and expression of CXXC4 abrogates the expression of a WNT-dependent reporter gene in L cells (Hino et al, 2001). In Xenopus, the CXXC4 homologue is expressed in neural tissue during and after the neurula stage and is required for anterior neural development (Michiue et al, 2004).

Literature References
PubMed ID Title Journal Year
15108311 XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus

Michiue, T, Fukui, A, Yukita, A, Sakurai, K, Danno, H, Kikuchi, A, Asashima, M

Dev. Dyn. 2004
10944533 Inhibition of Wnt signaling pathway by a novel axin-binding protein

Kadoya, T, Kishida, S, Fukui, A, Hinoi, T, Michiue, T, Asashima, M, Kikuchi, A

J. Biol. Chem. 2000
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