CXXC4 binds to DVL to negatively regulate WNT-dependent gene expression. CXXC4 competes with AXIN for DVL binding, and expression of CXXC4 abrogates the expression of a WNT-dependent reporter gene in L cells (Hino et al, 2001). In Xenopus, the CXXC4 homologue is expressed in neural tissue during and after the neurula stage and is required for anterior neural development (Michiue et al, 2004).
Kikuchi, A, Kadoya, T, Asashima, M, Hinoi, T, Michiue, T, Kishida, S, Fukui, A
Kikuchi, A, Danno, H, Yukita, A, Asashima, M, Michiue, T, Sakurai, K, Fukui, A
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