Reactome | CXXC4 binds DVL to prevent AXIN binding

CXXC4 binds DVL to prevent AXIN binding

Stable Identifier

R-HSA-5368582

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CXXC4 binds to DVL to negatively regulate WNT-dependent gene expression. CXXC4 competes with AXIN for DVL binding, and expression of CXXC4 abrogates the expression of a WNT-dependent reporter gene in L cells (Hino et al, 2001). In Xenopus, the CXXC4 homologue is expressed in neural tissue during and after the neurula stage and is required for anterior neural development (Michiue et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
10944533	Inhibition of Wnt signaling pathway by a novel axin-binding protein Kadoya, T, Kishida, S, Fukui, A, Hinoi, T, Michiue, T, Asashima, M, Kikuchi, A	J. Biol. Chem.	2000
15108311	XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus Michiue, T, Fukui, A, Yukita, A, Sakurai, K, Danno, H, Kikuchi, A, Asashima, M	Dev. Dyn.	2004