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MRPL46 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5368247
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
39S ribosomal protein L46, mitochondrial, RM46_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL46 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H2W6 MRPL46
Gene Names
MRPL46, C15orf4, LIECG2
Chain
transit peptide:1-, chain:-279
Reference Genes
BioGPS Gene:26589 MRPL46
COSMIC (genes):MRPL46 MRPL46
CTD Gene:26589 MRPL46
dbSNP Gene:26589 MRPL46
ENSEMBL:ENSG00000259494 MRPL46
ENSEMBL_homo_sapiens_GENE:ENSG00000259494.2 MRPL46
HGNC:1192 MRPL46
KEGG Gene (Homo sapiens):26589 MRPL46
Monarch:26589 MRPL46
NCBI Gene:26589 MRPL46
OMIM:611851 MRPL46
UCSC:Q9H2W6 MRPL46
Reference Transcript
RefSeq:NM_022163.3 MRPL46
Other Identifiers
11756687_a_at
16812982
219244_PM_s_at
219244_s_at
26589
3638049
3638050
3638059
3638063
3638066
3638067
7991209
91718_at
A_23_P37584
A_32_P209989
GE82670
GO:0003674
GO:0003735
GO:0005198
GO:0005634
GO:0005654
GO:0005739
GO:0005743
GO:0005762
GO:0005840
GO:0008150
GO:0030054
GO:0032543
GO:0043226
GO:0140053
GO:1990904
HMNXSV003020863
ILMN_1722838
PH_hs_0019802
PH_hs_0033283
TC15001816.hg
g11545915_3p_s_at
p33427
Participates
as a component of
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mrpl-46 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Mrpl46 [mitochondrial inner membrane]
(Mus musculus)
Mrpl46 [mitochondrial inner membrane]
(Rattus norvegicus)
MRPL46 [mitochondrial inner membrane]
(Bos taurus)
MRPL46 [mitochondrial inner membrane]
(Canis familiaris)
MRPL46 [mitochondrial inner membrane]
(Gallus gallus)
MRPL46 [mitochondrial inner membrane]
(Sus scrofa)
mRpL46 [mitochondrial inner membrane]
(Drosophila melanogaster)
mrpl46 [mitochondrial inner membrane]
(Danio rerio)
Cross References
RefSeq
NP_071446.2
OpenTargets
ENSG00000259494
HPA
ENSG00000259494-MRPL46
GeneCards
Q9H2W6
Ensembl
ENST00000312475
,
ENSG00000259494
,
ENSP00000312311
PRO
Q9H2W6
Pharos - Targets
Q9H2W6
PDB
7OIB
,
7A5I
,
7OIA
,
6I9R
,
5OOL
,
6ZSG
,
7OF0
,
7A5J
,
5OOM
,
7OF2
,
6NU2
,
6ZS9
,
6NU3
,
8PK0
,
3J7Y
,
6ZSA
,
7OF3
,
8QSJ
,
7ODT
,
7QI5
,
8OIR
,
8OIT
,
7ODS
,
7O9K
,
7A5F
,
7QI6
,
7L08
,
7PD3
,
6ZSE
,
7A5G
,
7O9M
,
6ZSD
,
7A5H
,
6ZM5
,
6ZM6
,
6VMI
,
3J9M
,
7ODR
,
7A5K
,
7OID
,
7PO4
,
7OIC
,
7OG4
,
7OIE
,
7QI4
,
7OF4
,
7OI7
,
7OI9
,
6ZSB
,
7OI8
,
7OF5
,
6ZSC
,
7L20
,
7OF6
,
8ANY
,
7OF7
,
6VLZ
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14561 NDUFAB1
4
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-9857608)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
0.528
2
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