Notum is a secreted protein with phospholipase C activity that has been implicated in promoting long range Hh signaling in Drosophila (Ayers et al, 2010; Eugster et al, 2007; Takeo et al, 2005; Han et al, 2005; Giraldez et al, 2002). Notum is thought to cleave the GPI-anchor from Dally, a Drosophila glypican, to release Hh-Dally complexes from the plasma membrane of the Hh-secreting cell (Ayers et al, 2010; Han et al, 2005), although this cleavage has not been directly demonstrated. In cultured mammalian cells, NOTUM has been shown to cleave the GPI anchor of a number of glypicans to promote their release from the plasma membrane (Traister et al, 2008).
Copley, RR, Cohen, SM, Giráldez, AJ
Akiyama, T, Firkus, C, Nakato, H, Aigaki, T, Takeo, S
Filmus, J, Traister, A, Shi, W
Lin, X, Yan, D, Han, C, Belenkaya, TY
Eugster, C, Mahmoud, A, Eaton, S, Panáková, D
Gallet, A, Ayers, KL, Thérond, PP, Staccini-Lavenant, L
phospholipase C activity of NOTUM [extracellular region]
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