Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling

Stable Identifier
R-HSA-5362551
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SCUBE2 is a member of a family of secreted proteins that is required for long-range signaling Hh signaling (Johnson et al, 2012; Tukachinsky et al, 2012; Creanga et al, 2013). Like DISP2, SCUBE2 binds to the cholesterol moiety of the Hh ligand, although the structural elements recognized by the two proteins are distinct. This suggests a model where Hh is released from the plasma membrane to the extracellular region via a DISP2 to SCUBE hand-off (Tukachinsky et al, 2012; Creanga et al, 2013).

Literature References
PubMed ID Title Journal Year
22902404 Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand

Tukachinsky, H, Kuzmickas, RP, Jao, CY, Liu, J, Salic, A

Cell Rep 2012
22609552 Scube activity is necessary for Hedgehog signal transduction in vivo

Johnson, JL, Hall, TE, Dyson, JM, Sonntag, C, Ayers, K, Berger, S, Gautier, P, Mitchell, C, Hollway, GE, Currie, PD

Dev. Biol. 2012
22677548 Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

Creanga, A, Glenn, TD, Mann, RK, Saunders, AM, Talbot, WS, Beachy, PA

Genes Dev. 2012
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