Reactome | Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling

Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling

Stable Identifier

R-HSA-5362551

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling

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SCUBE2 is a member of a family of secreted proteins that is required for long-range signaling Hh signaling (Johnson et al, 2012; Tukachinsky et al, 2012; Creanga et al, 2013). Like DISP2, SCUBE2 binds to the cholesterol moiety of the Hh ligand, although the structural elements recognized by the two proteins are distinct. This suggests a model where Hh is released from the plasma membrane to the extracellular region via a DISP2 to SCUBE hand-off (Tukachinsky et al, 2012; Creanga et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
22609552	Scube activity is necessary for Hedgehog signal transduction in vivo Johnson, JL, Hall, TE, Dyson, JM, Sonntag, C, Ayers, K, Berger, S, Gautier, P, Mitchell, C, Hollway, GE, Currie, PD	Dev. Biol.	2012
22902404	Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand Tukachinsky, H, Kuzmickas, RP, Jao, CY, Liu, J, Salic, A	Cell Rep	2012
22677548	Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form Creanga, A, Glenn, TD, Mann, RK, Saunders, AM, Talbot, WS, Beachy, PA	Genes Dev.	2012