ALDHs oxidise atRAL to atRA

Stable Identifier
R-HSA-5362522
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Several aldehyde dehydrogenases catalyse the irreversible oxidation of retinal to retinoic acid. ALDH1A1, 2 and 3 utilise NAD+ as cofactor to oxidise all-trans-retinal (atRAL) to all-trans-retinoic acid (atRA). They are cytosolic enzymes which are functional in their homotetrameric states (Yoshida et al. 1993, Duester 2008, Bchini et al. 2013).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
retinal dehydrogenase activity of ALDH1A1,2,3 tetramers [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created