ALDHs oxidise atRAL to atRA

Stable Identifier
R-HSA-5362522
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Several aldehyde dehydrogenases catalyse the irreversible oxidation of retinal to retinoic acid. ALDH1A1, 2 and 3 utilise NAD+ as cofactor to oxidise all-trans-retinal (atRAL) to all-trans-retinoic acid (atRA). They are cytosolic enzymes which are functional in their homotetrameric states (Yoshida et al. 1993, Duester 2008, Bchini et al. 2013).

Literature References
Participants
Participates
Catalyst Activity

retinal dehydrogenase activity of ALDH1A1,2,3 tetramers [cytosol]

Orthologous Events
Cross References
Rhea
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