TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Stable Identifier
R-HSA-5362500
Type
Reaction [omitted]
Species
Homo sapiens
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Upon stimulation by pathogen-associated inflammatory signals TANK associates with TRAF3 which results in K63-linked ubiquitination of TANK (Gatot JC et al. 2007). How the ubiquitination of TANK contributes to the activation of TBK1 and/or IKKepsilon remains unclear.

Literature References
PubMed ID Title Journal Year
17047224 Regulation and function of IKK and IKK-related kinases

Hacker, H, Karin, M

Sci STKE 2006
17823124 Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF

Gatot, JS, Gioia, R, Chau, TL, Patrascu, F, Warnier, M, Close, P, Chapelle, JP, Muraille, E, Brown, K, Siebenlist, U, Piette, J, Dejardin, E, Chariot, A

J. Biol. Chem. 2007
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