Upon stimulation by pathogen-associated inflammatory signals TANK associates with TRAF3 which results in K63-linked ubiquitination of TANK (Gatot JC et al. 2007). How the ubiquitination of TANK contributes to the activation of TBK1 and/or IKKepsilon remains unclear.
Hacker, H, Karin, M
Gatot, JS, Gioia, R, Chau, TL, Patrascu, F, Warnier, M, Close, P, Chapelle, JP, Muraille, E, Brown, K, Siebenlist, U, Piette, J, Dejardin, E, Chariot, A
© 2021 Reactome