Glycosylation of Hh

Stable Identifier
R-HSA-5362386
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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Glycosylation of Hh
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Proteomic studies show that the C-termini of SHH and IHH are N-glycosylated (Liu et al, 2005). A N278A mutant of SHH does not undergo cholesterol-mediated autoproteolysis suggesting that glycosylation is a prerequisite for this processing step (Huang et al, 2013).
Literature References
PubMed ID Title Journal Year
23867461 Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum

Ye, Y, Chu, YR, Hsiao, HT, Huang, CH, Chen, X

J. Biol. Chem. 2013
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Monroe, ME, Smith, RD, Qian, WJ, Moore, RJ, Camp, DG, Gritsenko, MA, Liu, T

J. Proteome Res. 2005
Participants
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Orthologous Events
Glycosylation of Hh (Bos taurus)
Glycosylation of Hh (Canis familiaris)
Glycosylation of Hh (Danio rerio)
Glycosylation of Hh (Drosophila melanogaster)
Glycosylation of Hh (Gallus gallus)
Glycosylation of Hh (Mus musculus)
Glycosylation of Hh (Rattus norvegicus)
Glycosylation of Hh (Sus scrofa)
Glycosylation of Hh (Xenopus tropicalis)
Authored
Rothfels, K  (2014-03-29)
Reviewed
Liu, Y C  (2014-05-16)
Created
Rothfels, K  (2014-04-16)
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