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DERL2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5362350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
FLANA, DER2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants are degraded by ERAD (Homo sapiens)
Hh processing variants are recruited to SEL1:SYVN at the ER membrane (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Hh processing variants are ubiquitinated (Homo sapiens)
SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
ABC transporter disorders (Homo sapiens)
Defective CFTR causes cystic fibrosis (Homo sapiens)
CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 and RNF185 ubiquitinate CFTR F508del (Homo sapiens)
CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Homo sapiens)
Calnexin/calreticulin cycle (Homo sapiens)
ER Quality Control Compartment (ERQC) (Homo sapiens)
OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 (Homo sapiens)
OS9:SEL1:ERAD E3 ligases:DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog ligand biogenesis (Homo sapiens)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)
DERL oligomer [endoplasmic reticulum membrane] (Homo sapiens)
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZP9 DERL2
Gene Names
DERL2, DER2, FLANA, CGI-101, SBBI53
Chain
chain:1-239
Reference Genes
BioGPS Gene:51009 DERL2
COSMIC (genes):DERL2 DERL2
CTD Gene:51009 DERL2
dbSNP Gene:51009 DERL2
ENSEMBL:ENSG00000072849 DERL2
HGNC:17943 DERL2
KEGG:hsa:51009 DERL2
Monarch:51009 DERL2
NCBI Gene:51009 DERL2
OMIM:610304 DERL2
UCSC:Q9GZP9 DERL2
Reference Transcript
RefSeq:NM_016041.4 DERL2
RefSeq:NM_001304779.1 DERL2
Other Identifiers
11717553_at
16840308
218333_PM_at
218333_at
226719_PM_at
226719_at
3742748
3742749
3742750
3742751
3742753
3742755
3742757
3742758
3742759
3742760
3742761
3742763
3742764
3742765
3742766
3742767
3742768
3742769
3742770
3742771
3742772
3742773
3742774
3742775
3742778
3742779
3742780
51009
53750_at
54635_at
78400_at
8011875
A_23_P118749
GE58661
GE741414
GO:0001967
GO:0005047
GO:0005515
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005789
GO:0006886
GO:0006950
GO:0006986
GO:0008284
GO:0010498
GO:0016020
GO:0030163
GO:0030307
GO:0030968
GO:0030970
GO:0031410
GO:0036503
GO:0043226
GO:0044877
GO:1904153
HMNXSV003018591
Hs.12489.0.A1_3p_at
ILMN_1761969
ILMN_1877068
PH_hs_0001189
PH_hs_0014799
TC17001058.hg
TC17002458.hg
g7705603_3p_at
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
OS9:SEL1:ERAD E3 ligases:DERL2 [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
DERLs [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
DERL2 [endoplasmic reticulum membrane]
(Bos taurus)
DERL2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
DERL2 [endoplasmic reticulum membrane]
(Canis familiaris)
DERL2 [endoplasmic reticulum membrane]
(Gallus gallus)
DERL2 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
DERL2 [endoplasmic reticulum membrane]
(Sus scrofa)
derl1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
derl2 [endoplasmic reticulum membrane]
(Danio rerio)
derl2 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Der-2 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Derl2 [endoplasmic reticulum membrane]
(Mus musculus)
Derl2 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000158771
,
ENSP00000158771
OpenTargets
ENSG00000072849
HPA
ENSG00000072849-DERL2
PRO
Q9GZP9
Pharos - Targets
Q9GZP9
GlyGen
Q9GZP9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.556
3
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