CTNNB1 S45 mutants aren't phosphorylated

Stable Identifier
R-HSA-5358751
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Pathway
Species
Homo sapiens
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S45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish the CK1alpha phosphorylation site of beta-catenin which acts as a critical priming site for GSK3 phosphorylation of T41( and subsequently S37 and S33) thus preventing its ubiquitin-mediated degradation (Morin et al, 1997; Amit et al, 2002).

Literature References
PubMed ID Title Journal Year
12000790 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

Andersen, JS, Birman, Y, Mann, M, Ben-Shushan, E, Alkalay, I, Hatzubai, A, Amit, S, Ben-Neriah, Y

Genes Dev 2002
9065402 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Barker, N, Clevers, HC, Morin, PJ, Kinzler, KW, Vogelstein, B, Korinek, V, Sparks, AB

Science 1997
10921899 Wnt signaling and cancer

Polakis, P

Genes Dev. 2000
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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BioModels Database
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