Reactome | DNA polymerase delta polymerizes DNA across single stranded gap

DNA polymerase delta polymerizes DNA across single stranded gap

Stable Identifier

R-HSA-5358579

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DNA polymerase delta polymerizes DNA across single stranded gap

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DNA polymerase delta synthesizes DNA across a single-stranded gap during mismatch repair (Longley et al. 1997, Zhang et al. 2005, Constantin et al. 2005, reviewed in Prindle and Loeb 2012). RPA stimulates the activity of DNA polymerase delta (Dong et al. 1999). DNA polymerase delta does not displace strands during synthesis (Randahl et al. 1988).

Literature References

PubMed ID	Title	Journal	Year
16143102	Reconstitution of 5'-directed human mismatch repair in a purified system Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM	Cell	2005
9882630	In vitro analysis of the zinc-finger motif in human replication protein A Dong, J, Park, JS, Lee, SH	Biochem. J.	1999
9099749	DNA polymerase delta is required for human mismatch repair in vitro Longley, MJ, Pierce, AJ, Modrich, P	J. Biol. Chem.	1997
23065663	DNA polymerase delta in DNA replication and genome maintenance Prindle, MJ, Loeb, LA	Environ. Mol. Mutagen.	2012
2842325	DNA-repair reactions by purified HeLa DNA polymerases and exonucleases Randahl, H, Elliott, GC, Linn, S	J. Biol. Chem.	1988
16188885	Human mismatch repair: reconstitution of a nick-directed bidirectional reaction Constantin, N, Dzantiev, L, Kadyrov, FA, Modrich, P	J. Biol. Chem.	2005