The latent endonuclease activity of MLH1:PMS2 (MutLalpha) is activated by interaction with MSH2:MSH6 and PCNA (Kadyrov et al 2006). MLH1:PMS2 makes a nick in the replicated strand of DNA. As inferred from yeast, more than one MLH1:PMS2 may bind per MSH2:MSH6 (Hombauer et al. 2011). Strand selection of the nick is determined by interaction with PCNA, though the exact mechanism is unknown (Pluciennik et al 2010).
Pluciennik, A, Dzantiev, L, Iyer, RR, Constantin, N, Kadyrov, FA, Modrich, P
Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM
Constantin, N, Dzantiev, L, Kadyrov, FA, Modrich, P
Hombauer, H, Campbell, CS, Smith, CE, Desai, A, Kolodner, RD
Kadyrov, FA, Dzantiev, L, Constantin, N, Modrich, P
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