p-T357,S358-MLKL oligomer [cytosol]

Stable Identifier
R-HSA-5357857
Type
Polymer
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
29930286 Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Petrie, EJ, Sandow, JJ, Jacobsen, AV, Smith, BJ, Griffin, MDW, Lucet, IS, Dai, W, Young, SN, Tanzer, MC, Wardak, A, Liang, LY, Cowan, AD, Hildebrand, JM, Kersten, WJA, Lessene, G, Silke, J, Czabotar, PE, Webb, AI, Murphy, JM

Nat Commun 2018
24316671 Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai, Z, Jitkaew, S, Zhao, J, Chiang, HC, Choksi, S, Liu, J, Ward, Y, Wu, LG, Liu, ZG

Nat. Cell Biol. 2014
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Participant Of
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Cross References
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