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EXO1 [nucleoplasm]
Stable Identifier
R-HSA-5357514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Exonuclease 1, EXO1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q99708 RBBP8
Expand all
DNA Repair (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
EXO1 [nucleoplasm] (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Homo sapiens)
EXO1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQ84 EXO1
Gene Names
EXO1, EXOI, HEX1
Chain
chain:1-846
Reference Genes
BioGPS Gene:9156 EXO1
COSMIC (genes):EXO1 EXO1
CTD Gene:9156 EXO1
dbSNP Gene:9156 EXO1
ENSEMBL:ENSG00000174371 EXO1
HGNC:3511 EXO1
KEGG Gene (Homo sapiens):9156 EXO1
Monarch:9156 EXO1
NCBI Gene:9156 EXO1
OMIM:606063 EXO1
UCSC:Q9UQ84 EXO1
Reference Transcript
RefSeq:XM_006711840.2 EXO1
RefSeq:NM_130398.3 EXO1
RefSeq:NM_003686.4 EXO1
RefSeq:NM_006027.4 EXO1
RefSeq:XM_011544321.1 EXO1
RefSeq:XM_011544322.1 EXO1
Other Identifiers
0002350632
0005890528
0103290037
11721209_a_at
16679411
204603_at
2388222
2388223
2388224
2388225
2388226
2388227
2388229
2388230
2388231
2388232
2388233
2388234
2388235
2388238
2388239
2388240
2388242
2388244
2388246
2388248
2388249
36041_at
7910997
9156
A_14_P137216
A_23_P23303
GE60476
GO:0000003
GO:0002376
GO:0002455
GO:0003674
GO:0003677
GO:0003682
GO:0003824
GO:0004518
GO:0004519
GO:0004523
GO:0004527
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005886
GO:0006259
GO:0006260
GO:0006281
GO:0006298
GO:0006310
GO:0006950
GO:0006974
GO:0007049
GO:0007165
GO:0008150
GO:0008409
GO:0009058
GO:0016446
GO:0016604
GO:0016787
GO:0016788
GO:0017108
GO:0022607
GO:0034641
GO:0035312
GO:0042592
GO:0043167
GO:0043226
GO:0045145
GO:0045190
GO:0046872
GO:0048256
GO:0048856
GO:0051276
GO:0051321
GO:0051908
GO:0090305
GO:0090502
GO:0090656
GO:1901796
ILMN_1673721
ILMN_1719089
ILMN_2351916
PH_hs_0003369
TC01001976.hg
g4504368_3p_at
Participant Of
input
EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha)
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)
hasComponent
EXO1:BLM,WRN [nucleoplasm]
EXO1:MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 or more bases and single strand incision [nucleoplasm]
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
Inferred To
tos [nucleoplasm] (Drosophila melanogaster)
EXO1 [nucleoplasm] (Bos taurus)
EXO1 [nucleoplasm] (Canis familiaris)
EXO1 [nucleoplasm] (Gallus gallus)
EXO1 [nucleoplasm] (Plasmodium falciparum)
EXO1 [nucleoplasm] (Saccharomyces cerevisiae)
EXO1 [nucleoplasm] (Sus scrofa)
exo-1 [nucleoplasm] (Caenorhabditis elegans)
exo1 [nucleoplasm] (Danio rerio)
exo1 [nucleoplasm] (Dictyostelium discoideum)
exo1 [nucleoplasm] (Schizosaccharomyces pombe)
exo1 [nucleoplasm] (Xenopus tropicalis)
Exo1 [nucleoplasm] (Mus musculus)
Exo1 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_003677.4
,
XP_011542623.1
,
NP_006018.4
,
XP_006711903.1
,
NP_569082.2
,
XP_011542624.1
OpenTargets
ENSG00000174371
GeneCards
Q9UQ84
HPA
ENSG00000174371-EXO1
Ensembl
ENST00000348581
,
ENSP00000430251
,
ENSP00000355506
,
ENST00000366548
,
ENST00000518483
,
ENSG00000174371
,
ENSP00000311873
PRO
Q9UQ84
PDB
5V0B
,
5V08
,
3QEA
,
5V04
,
5V0A
,
5V0E
,
5V07
,
5V0D
,
5UZV
,
3QE9
,
5V06
,
5V09
,
3QEB
,
5V0C
,
5V05
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99708 RBBP8
4
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
Ac-K432,K526,K604-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
0.656
4
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