PAK1-3 autophosphorylates

Stable Identifier
R-HSA-5357472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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PAK1-3 autophosphorylates
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Increased PAK1-3 catalytic activity is associated with autophosphorylation of key residues, including one site in the regulatory portion (S144 in PAK1) and another in the so-called activation loop (T423 in PAK1).

Literature References
PubMed ID Title Journal Year
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Gatti, A, Huang, Z, Tuazon, PT, Traugh, JA

J Biol Chem 1999
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Chong, C, Tan, L, Lim, L, Manser, E

J Biol Chem 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PAK1,2,3 dimer [cytosol]
Physical Entity
PAK1,2,3 dimer [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
PAK1-3 autophosphorylates (Bos taurus)
PAK1-3 autophosphorylates (Caenorhabditis elegans)
PAK1-3 autophosphorylates (Danio rerio)
PAK1-3 autophosphorylates (Drosophila melanogaster)
PAK1-3 autophosphorylates (Gallus gallus)
PAK1-3 autophosphorylates (Mus musculus)
PAK1-3 autophosphorylates (Rattus norvegicus)
PAK1-3 autophosphorylates (Sus scrofa)
PAK1-3 autophosphorylates (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2014-03-21)