PAK1-3 autophosphorylates

Stable Identifier
R-HSA-5357472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PAK1-3 autophosphorylates
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Increased PAK1-3 catalytic activity is associated with autophosphorylation of key residues, including one site in the regulatory portion (S144 in PAK1) and another in the so-called activation loop (T423 in PAK1).

Literature References
PubMed ID Title Journal Year
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Gatti, A, Huang, Z, Tuazon, PT, Traugh, JA

J Biol Chem 1999
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Chong, C, Tan, L, Lim, L, Manser, E

J Biol Chem 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PAK1,2,3 dimer [cytosol]
Physical Entity
PAK1,2,3 dimer [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
PAK1-3 autophosphorylates (Caenorhabditis elegans)
PAK1-3 autophosphorylates (Danio rerio)
PAK1-3 autophosphorylates (Drosophila melanogaster)
PAK1-3 autophosphorylates (Gallus gallus)
PAK1-3 autophosphorylates (Mus musculus)
PAK1-3 autophosphorylates (Rattus norvegicus)
PAK1-3 autophosphorylates (Sus scrofa)
PAK1-3 autophosphorylates (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2014-03-21)
Cite Us!