AXL binds SRC-1

Stable Identifier
R-HSA-5357432
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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AXL binds SRC-1
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AXL/UFO (Tyrosine-protein kinase receptor UFO) is a member of the TAM (Tyro3/Axl/Mer) family of receptor tyrosine kinases (RTKs). AXL has been implicated in angiogenesis because of its ability to promote angiogenically related cellular responses in endothelial cells (Holland et al, 2005). AXL is required for VEGFA-dependent activation of PI3K. Activated Src family kinases recruit AXL via its juxtamembrane domain and thereby trigger ligand-independent autophosphorylation of AXL that promotes association with PI3K and activation (Ruan & Kazlauskas 2012).

Literature References
PubMed ID Title Journal Year
22327215 Axl is essential for VEGF-A-dependent activation of PI3K/Akt

Ruan, GX, Kazlauskas, A

EMBO J. 2012
Participants
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Output
Participant Of
hasEvent
Orthologous Events
AXL binds SRC-1 (Bos taurus)
AXL binds SRC-1 (Canis familiaris)
AXL binds SRC-1 (Mus musculus)
AXL binds SRC-1 (Rattus norvegicus)
AXL binds SRC-1 (Sus scrofa)
AXL binds SRC-1 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2014-03-21)