AXL/UFO (Tyrosine-protein kinase receptor UFO) is a member of the TAM (Tyro3/Axl/Mer) family of receptor tyrosine kinases (RTKs). AXL has been implicated in angiogenesis because of its ability to promote angiogenically related cellular responses in endothelial cells (Holland et al, 2005). AXL is required for VEGFA-dependent activation of PI3K. Activated Src family kinases recruit AXL via its juxtamembrane domain and thereby trigger ligand-independent autophosphorylation of AXL that promotes association with PI3K and activation (Ruan & Kazlauskas 2012).
Ruan, GX, Kazlauskas, A
© 2021 Reactome
