Reactome | TPP1 [lysosomal lumen]

TPP1 [lysosomal lumen]

Stable Identifier

R-HSA-535504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Tripeptidyl-peptidase 1, TPP1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q6P3S6 FBX42

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of TPP1 (Homo sapiens)
        
        TPP1 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14773 TPP1

Gene Names

TPP1, CLN2, GIG1, UNQ267/PRO304

Chain

signal peptide:1-19, propeptide:20-195, chain:196-563

Reference Genes

BioGPS Gene:1200 TPP1

COSMIC (genes):TPP1 TPP1

CTD Gene:1200 TPP1

dbSNP Gene:1200 TPP1

ENSEMBL:ENSG00000166340 TPP1

HGNC:2073 TPP1

KEGG:hsa:1200 TPP1

Monarch:1200 TPP1

NCBI Gene:1200 TPP1

OMIM:607998 TPP1

UCSC:O14773 TPP1

Reference Transcript

RefSeq:NM_000391.3 TPP1

Participates

as an output of

Expression of TPP1 (Homo sapiens)

Cross References

ENSEMBL

ENST00000645620, ENST00000533371, ENSG00000166340, ENSP00000493657, ENST00000647152, ENST00000299427, ENSP00000299427, ENSP00000437066, ENSP00000495893, ENST00000642892, ENSP00000494165

OpenTargets

ENSG00000166340

GeneCards

TPP1

HPA

ENSG00000166340-TPP1

PRO

O14773

Pharos - Targets

O14773

GlyGen

O14773

Orphanet

TPP1

HMDB Protein

HMDBP14587

PDB

3EDY, 3EE6

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53EZ4 CEP55			0.556	3
UniProt:Q6P3S6 FBX42			0.556	3
UniProt:Q9NSE2 CISH	1	CISH [cytosol] (R-HSA-1169213)	0.556	3
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.556	3
UniProt:Q8NAP3 ZBT38			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:Q9NWX5-2 Q9NWX52			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:P45974-2 USP5			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:E5LBV4 E5LBV4			0.524	2
UniProt:Q15388 TOMM20	6	PolyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-6783144) TOMM20 [mitochondrial outer membrane] (R-HSA-1252091) Ub-TOMM20 [mitochondrial outer membrane] (R-HSA-9834976) K48polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843324) K63polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843313) p-S65-Ub:TOMM20 [mitochondrial outer membrane] (R-HSA-9834948)	0.483	3

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