Reactome | HAVCR2 [plasma membrane]

HAVCR2 [plasma membrane]

Stable Identifier

R-HSA-5340408

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Hepatitis A virus cellular receptor 2, HAVR2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P23458 JAK1

Expand all

External Reference Information

External Reference

UniProt:Q8TDQ0 HAVCR2

Gene Names

HAVCR2, TIM3, TIMD3

Chain

signal peptide:1-21, chain:22-301

Reference Genes

BioGPS Gene:84868 HAVCR2

COSMIC (genes):HAVCR2 HAVCR2

CTD Gene:84868 HAVCR2

dbSNP Gene:84868 HAVCR2

ENSEMBL:ENSG00000135077 HAVCR2

ENSEMBL_homo_sapiens_GENE:ENSG00000135077.10 HAVCR2

HGNC:18437 HAVCR2

KEGG Gene (Homo sapiens):84868 HAVCR2

Monarch:84868 HAVCR2

NCBI Gene:84868 HAVCR2

OMIM:606652 HAVCR2

UCSC:Q8TDQ0 HAVCR2

Reference Transcript

RefSeq:NM_032782.4 HAVCR2

Other Identifiers

11728228_at

11728229_a_at

1554285_PM_at

1554285_at

1555628_PM_a_at

1555628_a_at

17002141

235458_PM_at

235458_at

2883350

2883351

2883352

2883353

2883354

2883355

2883356

2883358

2883360

2883361

2883362

2883364

2883369

2883371

2883372

75648_at

8115464

84868

A_23_P18903

A_24_P923370

GE83516

GO:0001772

GO:0001819

GO:0002250

GO:0002281

GO:0002376

GO:0002519

GO:0002652

GO:0002826

GO:0002838

GO:0002859

GO:0005515

GO:0005634

GO:0005768

GO:0005769

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0007155

GO:0009986

GO:0010629

GO:0016020

GO:0016592

GO:0022414

GO:0023052

GO:0030886

GO:0031410

GO:0032088

GO:0032480

GO:0032687

GO:0032689

GO:0032703

GO:0032712

GO:0032715

GO:0032720

GO:0032722

GO:0032729

GO:0032732

GO:0032753

GO:0032760

GO:0032815

GO:0034138

GO:0034154

GO:0034162

GO:0042102

GO:0042130

GO:0043032

GO:0043226

GO:0045087

GO:0045089

GO:0045824

GO:0046872

GO:0048856

GO:0050830

GO:0060135

GO:0070161

GO:0070374

GO:0071222

GO:0071656

GO:0098542

GO:1900425

GO:1900426

GO:1901224

GO:2000521

GO:2001189

HMNXSV003037666

Hs.155111.0.A1_3p_at

Hs2.155111.2.S1_3p_at

Hs2.155111.3.A1_3p_a_at

ILMN_1693826

PH_hs_0009342

PH_hs_0031885

TC05003434.hg

Participates

as a component of

HAVCR2:LGALS9 [plasma membrane] (Homo sapiens)

as an input of

HAVCR2 binds LGALS9 (Homo sapiens)

Cross References

RefSeq

NP_116171.3

Guide to Pharmacology - Targets

2940

OpenTargets

ENSG00000135077

HPA

ENSG00000135077-HAVCR2

GeneCards

Q8TDQ0

Ensembl

ENST00000696899, ENSP00000512960, ENSG00000135077, ENSP00000312002, ENST00000307851

PRO

Q8TDQ0

Pharos - Targets

Q8TDQ0

Orphanet

28031

PDB

6TXZ, 7M41, 5F71, 7M3Z, 6DHB, 7M3Y, 8HGJ, 7KQL, 5DZL

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.597	3
UniProt:P13688 CEACAM1	3	CEACAM1 [specific granule membrane] (R-HSA-6799528) CEACAM1 [plasma membrane] (R-HSA-197701) CEACAM1 [tertiary granule membrane] (R-HSA-6800953)	0.591	4
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q8N2M4 TM86A			0.556	3
UniProt:P36894 BMPR1A	2	BMPR1A [plasma membrane] (R-HSA-201480) p-4S-BMPR1A [plasma membrane] (R-HSA-201448)	0.527	2
UniProt:O14939 PLD2	2	PLD2 [plasma membrane] (R-HSA-2029075) PLD2 [endoplasmic reticulum membrane] (R-HSA-1498791)	0.527	2
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.527	2
UniProt:P0C7P0 CISD3			0.527	2
UniProt:Q8TCG2 PI4K2B	1	PI4K2B [cytosol] (R-HSA-1604675)	0.527	2
UniProt:Q643R3 LPCAT4	1	LPCAT4 [endoplasmic reticulum membrane] (R-HSA-1498768)	0.527	2
UniProt:Q96S97 MYADM			0.527	3
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.527	2
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.527	2
UniProt:Q9Y2I1 NISCH	1	NISCH [cytosol] (R-HSA-9691384)	0.527	2
UniProt:Q08357 SLC20A2	7	SLC20A2 V195Lfs61 [plasma membrane] (R-HSA-5625150) SLC20A2 L170 [plasma membrane] (R-HSA-5625074) SLC20A2 [plasma membrane] (R-HSA-427661) SLC20A2 G498R [plasma membrane] (R-HSA-5625140) SLC20A2 S601L [plasma membrane] (R-HSA-5625095) SLC20A2 T595M [plasma membrane] (R-HSA-5625111) SLC20A2 S610Afs*17 [plasma membrane] (R-HSA-5625137)	0.527	2
UniProt:O94832 MYO1D			0.527	2
UniProt:O95789 ZMYM6			0.527	2
UniProt:Q96BI1 SLC22A18	3	SLC22A18 [plasma membrane] (R-HSA-561110) SLC22A18 S233F [plasma membrane] (R-HSA-5625564) SLC22A18 R286H [plasma membrane] (R-HSA-5625583)	0.527	2
UniProt:Q8NB78 KDM1B	1	KDM1B [nucleoplasm] (R-HSA-5423072)	0.527	2
UniProt:P27037 ACVR2A	1	ACVR2A [plasma membrane] (R-HSA-201659)	0.527	2
UniProt:Q8TCT0 CERK	1	CERK [plasma membrane] (R-HSA-1631584)	0.527	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.527	2
UniProt:Q969X6 UTP4	1	CIRH1A [nucleoplasm] (R-HSA-6790662)	0.527	2
UniProt:Q14680 MELK			0.527	2
UniProt:Q6P5Z2 PKN3	2	p-T718-PKN3 [cytosol] (R-HSA-5623654) PKN3 [cytosol] (R-HSA-5623611)	0.527	2
UniProt:P52824 DGKQ	1	DGKQ [plasma membrane] (R-HSA-426062)	0.527	2
UniProt:Q53EQ6 TIGD5			0.527	2
UniProt:Q8IWF6 DENND6A	1	DENND6A [cytosol] (R-HSA-8876587)	0.527	2
UniProt:Q7Z5G4 GOLGA7	3	GOLGA7 [extracellular region] (R-HSA-6800449) GOLGA7 [tertiary granule lumen] (R-HSA-6800164) GOLGA7 [Golgi membrane] (R-HSA-9647777)	0.527	2
UniProt:A6NFQ2 TCAF2			0.527	2
UniProt:Q5TCX8 M3K21			0.527	2
UniProt:Q9P265 DIP2B			0.527	2
UniProt:Q16513 PKN2	2	p-T816-PKN2 [cytosol] (R-HSA-5623652) PKN2 [cytosol] (R-HSA-5623612)	0.527	2
UniProt:O60346 PHLPP1	1	PHLPP1 [cytosol] (R-HSA-199421)	0.527	2
UniProt:P78357 CNTNAP1	1	CNTNAP1 [plasma membrane] (R-HSA-373626)	0.527	2
UniProt:O00443 PIK3C2A	3	PIK3C2A [Golgi membrane] (R-HSA-432679) PIK3C2A [cytosol] (R-HSA-1604624) PIK3C2A [cytoplasmic vesicle membrane] (R-HSA-432683)	0.527	2
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.527	2
UniProt:Q99943 AGPAT1	1	AGPAT1 [endoplasmic reticulum membrane] (R-HSA-61803)	0.527	3
UniProt:P29597 TYK2	5	p-TYK2 [cytosol] (R-HSA-8950424) p-Y-TYK2 [cytosol] (R-HSA-6784366) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.527	2
UniProt:P41732 TSPAN7	1	TSPAN7 [plasma membrane] (R-HSA-400337)	0.527	2
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.527	2
UniProt:P0DTD8 NS7B			0.488	2
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.462	2
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.462	3
UniProt:P43403 ZAP70	3	ZAP70 [cytosol] (R-HSA-202397) p-Y493-ZAP70 [cytosol] (R-HSA-202368) p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)	0.462	2
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.462	3
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.462	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.462	2

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