GLTP transports GSL from plasma membrane to ER membrane

Stable Identifier
Reaction [transition]
Homo sapiens
GLTP transports glycosphingolipids from plasma membrane to ER membrane
Locations in the PathwayBrowser
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Glycolipid transfer protein (GLTP) is a monomeric, soluble protein that can mediate the intermembrane transport of glycosphingolipids (GSLs) (Malinina et al., 2004; Malinina et al., 2006; Tuuf & Mattjus 2007). GLTPs could be potential regulators of cell processes mediated by GSLs, such as differentiation and proliferation to invasive adhesion, neurodegeneration, and apoptosis (reviewed in Mishra et al., 2020). This reaction shows one example of GSL transfer from the plasma membrane to the ER membrane.
Literature References
PubMed ID Title Journal Year
17980653 Human glycolipid transfer protein--intracellular localization and effects on the sphingolipid synthesis

Mattjus, P, Tuuf, J

Biochim. Biophys. Acta 2007
32339554 Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death

Chalfant, CE, Hinchcliffe, EH, Mishra, SK, Gao, YG, Zou, X, Stephenson, DJ, Malinina, L, Brown, RE

Prog Lipid Res 2020
17105344 The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure

Abagyan, R, Lu, M, Kanack, AT, Malinina, L, Malakhova, ML, Patel, DJ, Brown, RE

PLoS Biol. 2006
15329726 Structural basis for glycosphingolipid transfer specificity

Teplov, A, Malinina, L, Malakhova, ML, Patel, DJ, Brown, RE

Nature 2004
Catalyst Activity

glycolipid transfer activity of GLTP [cytosol]

Orthologous Events
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