Reactome | NR1H4 [nucleoplasm]

NR1H4 [nucleoplasm]

Stable Identifier

R-HSA-5340228

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bile acid receptor, NR1H4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96RI1 NR1H4

Gene Names

NR1H4, BAR, FXR, HRR1, RIP14

Chain

chain:1-486

Reference Genes

BioGPS Gene:9971 NR1H4

COSMIC (genes):NR1H4 NR1H4

CTD Gene:9971 NR1H4

dbSNP Gene:9971 NR1H4

ENSEMBL:ENSG00000012504 NR1H4

HGNC:7967 NR1H4

KEGG:hsa:9971 NR1H4

Monarch:9971 NR1H4

NCBI Gene:9971 NR1H4

OMIM:603826 NR1H4

UCSC:Q96RI1 NR1H4

Reference Transcript

Participates

as an input of

NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)

as a component of

NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)

Inferred To

nr1h4 [nucleoplasm] (Danio rerio)

nr1h4 [nucleoplasm] (Xenopus tropicalis)

FXR [nucleoplasm] (Gallus gallus)

EcR [nucleoplasm] (Drosophila melanogaster)

NR1H4 [nucleoplasm] (Bos taurus)

NR1H4 [nucleoplasm] (Canis familiaris)

NR1H4 [nucleoplasm] (Mus musculus)

NR1H4 [nucleoplasm] (Rattus norvegicus)

NR1H4 [nucleoplasm] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

603

OpenTargets

ENSG00000012504

ENSEMBL

ENSP00000376712, ENST00000648861, ENST00000188403, ENST00000392986, ENSG00000012504, ENSP00000448506, ENST00000551379, ENST00000549996, ENSP00000448978, ENSP00000447149, ENSP00000496908, ENST00000548884, ENSP00000188403

ZINC - FDA approved

NR1H4_HUMAN

ZINC - Substances

NR1H4_HUMAN

ZINC - Biogenic

NR1H4_HUMAN

ZINC target

Q96RI1

PRO

Q96RI1

PDB

5Q19, 3OLF, 3OKI, 5Y49, 3RVF, 6A5Z, 5Y44, 5Q0L, 5Q0M, 5Q1G, 5Q0P, 5Q1A, 5Q0Q, 5Q0W, 3FXV, 5Q0V, 7TRB, 5Y1J, 5Q10, 5Q0Y, 3DCU, 5Q0R, 6HL1, 5Q0K, 5Q14, 3RUT, 5YXL, 5YXB, 3BEJ, 7VUE, 6A5X, 3HC6, 3P89, 6HL0, 4WVD, 3OMM, 3OMK, 5Q16, 5Q15, 5IAW, 5Q1E, 4QE8, 8HD3, 3DCT, 5Q0Z, 6A60, 3OKH, 7D42, 3OOK, 6A5W, 5Q1B, 5Q1H, 5Q12, 5YXD, 3OOF, 5Q18, 5Z12, 5Q1I, 5Q17, 3FLI, 5Q1D, 5Q0N, 5Q1C, 5Q0O, 8HBM, 5Q0X, 5YXJ, 3RUU, 5Q0J, 5Q0S, 5Q0I, 5Q11, 4OIV, 6A5Y, 3P88, 5Q13, 5WZX, 1OSH, 6ITM, 3HC5, 5ICK, 5Q0U, 5Q0T, 5Q1F, 3GD2, 3L1B

ZINC - Investigational

NR1H4_HUMAN

ZINC - Metabolites

NR1H4_HUMAN

HPA

ENSG00000012504-NR1H4

GeneCards

NR1H4

Pharos - Targets

Q96RI1

Orphanet

NR1H4

ZINC - Predictions - Purchasable

NR1H4_HUMAN

HMDB Protein

HMDBP02506

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.633	5
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.558	4
UniProt:FGF19 ENSG00000162344			0.527	2
UniProt:O75151 PHF2	1	PHF2 [nucleoplasm] (R-HSA-5423093)	0.525	2
IntAct:EBI-11173918 IR1			0.524	2
IntAct:EBI-11173879 P1			0.524	4
IntAct:EBI-11173957 P4			0.524	4
IntAct:EBI-11173936 P2			0.524	4