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NR1H4 [nucleoplasm]
Stable Identifier
R-HSA-5340228
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Bile acid receptor, NR1H4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of CYP7A1 (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NR1H4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96RI1 NR1H4
Gene Names
NR1H4, BAR, FXR, HRR1, RIP14
Chain
chain:1-486
Reference Genes
BioGPS Gene:9971 NR1H4
COSMIC (genes):NR1H4 NR1H4
CTD Gene:9971 NR1H4
dbSNP Gene:9971 NR1H4
ENSEMBL:ENSG00000012504 NR1H4
HGNC:7967 NR1H4
KEGG:hsa:9971 NR1H4
Monarch:9971 NR1H4
NCBI Gene:9971 NR1H4
OMIM:603826 NR1H4
UCSC:Q96RI1 NR1H4
Reference Transcript
RefSeq:NM_001206979.1 NR1H4
RefSeq:NM_001206992.1 NR1H4
RefSeq:NM_001206977.1 NR1H4
RefSeq:NM_001206978.1 NR1H4
RefSeq:NM_001206993.1 NR1H4
RefSeq:XM_011539040.2 NR1H4
RefSeq:NM_005123.3 NR1H4
Participates
as an input of
NR1H4 binds DCA, CDCA, LCHA (Homo sapiens)
as a component of
NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
Inferred To
nr1h4 [nucleoplasm]
(Danio rerio)
nr1h4 [nucleoplasm]
(Xenopus tropicalis)
FXR [nucleoplasm]
(Gallus gallus)
EcR [nucleoplasm]
(Drosophila melanogaster)
NR1H4 [nucleoplasm]
(Bos taurus)
NR1H4 [nucleoplasm]
(Canis familiaris)
NR1H4 [nucleoplasm]
(Mus musculus)
NR1H4 [nucleoplasm]
(Rattus norvegicus)
NR1H4 [nucleoplasm]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
603
OpenTargets
ENSG00000012504
ENSEMBL
ENSP00000376712
,
ENST00000648861
,
ENST00000188403
,
ENST00000392986
,
ENSG00000012504
,
ENSP00000448506
,
ENST00000551379
,
ENST00000549996
,
ENSP00000448978
,
ENSP00000447149
,
ENSP00000496908
,
ENST00000548884
,
ENSP00000188403
ZINC - FDA approved
NR1H4_HUMAN
ZINC - Substances
NR1H4_HUMAN
ZINC - Biogenic
NR1H4_HUMAN
ZINC target
Q96RI1
PRO
Q96RI1
PDB
5Q19
,
3OLF
,
3OKI
,
5Y49
,
3RVF
,
6A5Z
,
5Y44
,
5Q0L
,
5Q0M
,
5Q1G
,
5Q0P
,
5Q1A
,
5Q0Q
,
5Q0W
,
3FXV
,
5Q0V
,
7TRB
,
5Y1J
,
5Q10
,
5Q0Y
,
3DCU
,
5Q0R
,
6HL1
,
5Q0K
,
5Q14
,
3RUT
,
5YXL
,
5YXB
,
3BEJ
,
7VUE
,
6A5X
,
3HC6
,
3P89
,
6HL0
,
4WVD
,
3OMM
,
3OMK
,
5Q16
,
5Q15
,
5IAW
,
5Q1E
,
4QE8
,
8HD3
,
3DCT
,
5Q0Z
,
6A60
,
3OKH
,
7D42
,
3OOK
,
6A5W
,
5Q1B
,
5Q1H
,
5Q12
,
5YXD
,
3OOF
,
5Q18
,
5Z12
,
5Q1I
,
5Q17
,
3FLI
,
5Q1D
,
5Q0N
,
5Q1C
,
5Q0O
,
8HBM
,
5Q0X
,
5YXJ
,
3RUU
,
5Q0J
,
5Q0S
,
5Q0I
,
5Q11
,
4OIV
,
6A5Y
,
3P88
,
5Q13
,
5WZX
,
1OSH
,
6ITM
,
3HC5
,
5ICK
,
5Q0U
,
5Q0T
,
5Q1F
,
3GD2
,
3L1B
ZINC - Investigational
NR1H4_HUMAN
ZINC - Metabolites
NR1H4_HUMAN
HPA
ENSG00000012504-NR1H4
GeneCards
NR1H4
Pharos - Targets
Q96RI1
Orphanet
NR1H4
ZINC - Predictions - Purchasable
NR1H4_HUMAN
HMDB Protein
HMDBP02506
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WTS6 SETD7
1
SETD7 [nucleoplasm]
(R-HSA-1183221)
0.633
5
UniProt:Q15788 NCOA1
3
NCOA1 [nucleoplasm]
(R-HSA-442496)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
0.558
4
UniProt:FGF19 ENSG00000162344
0.527
2
UniProt:O75151 PHF2
1
PHF2 [nucleoplasm]
(R-HSA-5423093)
0.525
2
IntAct:EBI-11173918 IR1
0.524
2
IntAct:EBI-11173879 P1
0.524
4
IntAct:EBI-11173957 P4
0.524
4
IntAct:EBI-11173936 P2
0.524
4
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