Reactome | CSN polymer binds CaPO4

CSN polymer binds CaPO4

Stable Identifier

R-HSA-5340124

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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In milk, caseins (CSNs) interact with calcium phosphate (CaPO4), forming large stable colloidal particles called micelles. These micelles make it possible to maintain a supersaturated CaPO4 concentration in milk, providing the newborn with sufficient calcium phosphate for the mineralisation of calcified tissues. Human alpha-S1-casein (CSN1S1) is able to bind CaPO4 in milk. CSN1S1 forms a disulfide cross-linked heteropolymer with kappa-casein (CSN3), another CSN that is thought to stabilise micelle formation and thus preventing casein precipitation in milk (Brignon et al. 1985, Rasmussen et al. 1995, Johnson et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7619062	Characterization of three types of human alpha s1-casein mRNA transcripts Johnsen, LB, Berglund, L, Rasmussen, LK, Petersen, TE	Biochem. J.	1995
7749638	Human alpha s1-casein: purification and characterization Due, HA, Rasmussen, LK, Petersen, TE	Comp. Biochem. Physiol. B, Biochem. Mol. Biol.	1995
4018271	Preparation and amino acid sequence of human kappa-casein Ribadeau-Dumas, B, Brignon, G, Chtourou, A	FEBS Lett.	1985