CSN polymer binds CaPO4

Stable Identifier
R-HSA-5340124
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In milk, caseins (CSNs) interact with calcium phosphate (CaPO4), forming large stable colloidal particles called micelles. These micelles make it possible to maintain a supersaturated CaPO4 concentration in milk, providing the newborn with sufficient calcium phosphate for the mineralisation of calcified tissues. Human alpha-S1-casein (CSN1S1) is able to bind CaPO4 in milk. CSN1S1 forms a disulfide cross-linked heteropolymer with kappa-casein (CSN3), another CSN that is thought to stabilise micelle formation and thus preventing casein precipitation in milk (Brignon et al. 1985, Rasmussen et al. 1995, Johnson et al. 1995).

Literature References
PubMed ID Title Journal Year
7749638 Human alpha s1-casein: purification and characterization

Rasmussen, LK, Due, HA, Petersen, TE

Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 1995
7619062 Characterization of three types of human alpha s1-casein mRNA transcripts

Johnsen, LB, Rasmussen, LK, Petersen, TE, Berglund, L

Biochem. J. 1995
4018271 Preparation and amino acid sequence of human kappa-casein

Brignon, G, Chtourou, A, Ribadeau-Dumas, B

FEBS Lett. 1985
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