Uptake and actions of bacterial toxins

Stable Identifier
R-HSA-5339562
Type
Pathway
Species
Homo sapiens
Related Species
Corynephage beta, Clostridium botulinum, Bacillus anthracis, Clostridium tetani
ReviewStatus
5/5
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Uptake and actions of bacterial toxins
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The toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of the ones annotated here share a bipartiite mechanism of host intoxication: one moiety binds target cells and mediates the delivery of the other part to the intracellular compartment where it can function as an enzyme to degrade or derivatize and inactivate critical target cell proteins or to activate constitutive synthesis of high levels of cAMP.
Literature References
PubMed ID Title Journal Year
20358680 Toxins from bacteria

Baldwin, MR, Barbieri, JT, Henkel, JS

EXS 2010
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Events
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as an event of
Disease
Created
D'Eustachio, P  (2014-03-05)
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