GLTPD1 transports C1P from plasma membrane to Golgi membrane

Stable Identifier
R-HSA-5339535
Type
Reaction [transition]
Species
Homo sapiens
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Ceramide-1-phosphate transfer protein (GLTPD1) mediates the intracellular transfer of ceramide-1-phosphate (C1P) between the cell membrane and organelle membranes. C1P is an activator of group IVA cytosolic phospholipase (PLA2G4A), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, which contributes to disease pathogenesis. To avoid the effects of chronic inflammation, cells require efficient targeting, trafficking and presentation of C1P to specific cellular sites. GLTPD1 is localised in the cytosol but can associate with plamsa, Golgi and nuclear membranes (Simanshu et al. 2013).

Literature References
PubMed ID Title Journal Year
23863933 Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

Simanshu, DK, Kamlekar, RK, Wijesinghe, DS, Zou, X, Zhai, X, Mishra, SK, Molotkovsky, JG, Malinina, L, Hinchcliffe, EH, Chalfant, CE, Brown, RE, Patel, DJ

Nature 2013
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Catalyst Activity
Title
ceramide 1-phosphate transfer activity of GLTPD1 [cytosol]
Physical Entity
Activity
Orthologous Events
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