Reactome | CPTP transports C1P from plasma membrane to Golgi membrane

CPTP transports C1P from plasma membrane to Golgi membrane

Stable Identifier

R-HSA-5339535

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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CPTP transports C1P from plasma membrane to Golgi membrane

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Ceramide-1-phosphate transfer protein (CPTP, GLTPD1) mediates the intracellular transfer of ceramide-1-phosphate (C1P) between the cell membrane and organelle membranes. C1P is an activator of group IVA cytosolic phospholipase (PLA2G4A), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, contributing to disease pathogenesis. To avoid the effects of chronic inflammation, cells require efficient targeting, trafficking, and presentation of C1P to specific cellular sites. CPTP is localized in the cytosol but can be associated with plasma, Golgi, and nuclear membranes (Simanshu et al., 2013; reviewed in Mishra et al., 2020; Zhang et al., 2021). The transport reaction shown here is between plasma and the Golgi membrane.

Literature References

PubMed ID	Title	Journal	Year
32339554	Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death Mishra, SK, Gao, YG, Zou, X, Stephenson, DJ, Malinina, L, Hinchcliffe, EH, Chalfant, CE, Brown, RE	Prog Lipid Res	2020
23863933	Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids Simanshu, DK, Kamlekar, RK, Wijesinghe, DS, Zou, X, Zhai, X, Mishra, SK, Molotkovsky, JG, Malinina, L, Hinchcliffe, EH, Chalfant, CE, Brown, RE, Patel, DJ	Nature	2013
34499882	Ceramide-1-phosphate and its transfer proteins in eukaryotes Zhang, Y, Zhang, X, Lu, M, Zou, X	Chem Phys Lipids	2021