CPTP transports C1P from plasma membrane to Golgi membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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Ceramide-1-phosphate transfer protein (CPTP, GLTPD1) mediates the intracellular transfer of ceramide-1-phosphate (C1P) between the cell membrane and organelle membranes. C1P is an activator of group IVA cytosolic phospholipase (PLA2G4A), the rate-limiting releaser of arachidonic acid used for pro-inflammatory eicosanoid production, contributing to disease pathogenesis. To avoid the effects of chronic inflammation, cells require efficient targeting, trafficking, and presentation of C1P to specific cellular sites. CPTP is localized in the cytosol but can be associated with plasma, Golgi, and nuclear membranes (Simanshu et al., 2013; reviewed in Mishra et al., 2020; Zhang et al., 2021). The transport reaction shown here is between plasma and the Golgi membrane.

Literature References
PubMed ID Title Journal Year
32339554 Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death

Chalfant, CE, Hinchcliffe, EH, Mishra, SK, Gao, YG, Zou, X, Stephenson, DJ, Malinina, L, Brown, RE

Prog Lipid Res 2020
23863933 Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

Chalfant, CE, Hinchcliffe, EH, Mishra, SK, Zou, X, Kamlekar, RK, Zhai, X, Malinina, L, Molotkovsky, JG, Patel, DJ, Wijesinghe, DS, Brown, RE, Simanshu, DK

Nature 2013
34499882 Ceramide-1-phosphate and its transfer proteins in eukaryotes

Zhang, Y, Zou, X, Zhang, X, Lu, M

Chem Phys Lipids 2021
Catalyst Activity

ceramide 1-phosphate transfer activity of CPTP [cytosol]

Orthologous Events
Cross References
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