TUSC3 transports Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-5339528
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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TUSC3 transports Mg2+ from extracellular region to cytosol
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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Tumor suppressor candidate 3 (TUSC3) is expressed in most non-lymphoid cells and tissues and is an essential protein in Mg2+ uptake into cells (Zhou & Clapham 2009).

Literature References
PubMed ID Title Journal Year
19717468 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development

Zhou, H, Clapham, DE

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

magnesium ion transmembrane transporter activity of TUSC3(1-348) [plasma membrane]

Physical Entity
TUSC3(1-348) [plasma membrane] (Homo sapiens)
Activity
magnesium ion transmembrane transporter activity (GO:0015095)
Orthologous Events
TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
TUSC3 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
TUSC3 transports Mg2+ from extracellular region to cytosol (Danio rerio)
TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
TUSC3 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
TUSC3 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Mus musculus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
TUSC3 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2014-03-04)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-03-04)
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