TUSC3 transports Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-5339528
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Tumor suppressor candidate 3 (TUSC3) is expressed in most non-lymphoid cells and tissues and is an essential protein in Mg2+ uptake into cells (Zhou & Clapham 2009).

Literature References
PubMed ID Title Journal Year
19717468 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development

Zhou, H, Clapham, DE

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
magnesium ion transmembrane transporter activity of TUSC3(1-348) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!