MRS2 transports Mg2+ from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-5336466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial inner membrane, mitochondrial matrix
ReviewStatus
5/5
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MRS2 transports Mg2+ from cytosol to mitochondrial matrix
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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporter MRS2 homolog, mitochondrial (MRS2) mediates the influx of Mg2+ into the mitochondrial matrix (Zsurka et al. 2001). MRS2 is located on the inner mitochondrial membrane and its expression in yeast with a Mrs2-1 knock-out mutant partly restores mitochondrial magnesium concentrations that are otherwise much reduced (Zsurka et al. 2001).
Literature References
PubMed ID Title Journal Year
11401429 The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter

Zsurka, G, Gregán, J, Schweyen, RJ

Genomics 2001
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Catalyst Activity

magnesium ion transmembrane transporter activity of MRS2 [mitochondrial inner membrane]

Physical Entity
MRS2 [mitochondrial inner membrane] (Homo sapiens)
Activity
magnesium ion transmembrane transporter activity (GO:0015095)
Orthologous Events
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Canis familiaris)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Danio rerio)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)
MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2014-03-03)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-03-03)
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