MRS2 transports Mg2+ from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-5336466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporter MRS2 homolog, mitochondrial (MRS2) mediates the influx of Mg2+ into the mitochondrial matrix (Zsurka et al. 2001). MRS2 is located on the inner mitochondrial membrane and its expression in yeast with a Mrs2-1 knock-out mutant partly restores mitochondrial magnesium concentrations that are otherwise much reduced (Zsurka et al. 2001).

Literature References
PubMed ID Title Journal Year
11401429 The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter

Zsurka, G, Gregán, J, Schweyen, RJ

Genomics 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
magnesium ion transmembrane transporter activity of MRS2 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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