NIPAs transport Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-5336453
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporters NIPA1, 2, 3, 4 (NIPA1,2,3,4) and NIPA-like proteins 2 and 2 (NIPAL2 and 3) can act as Mg2+ transporters. They may also transport other divalent cations such as Fe2+, Mn2+ and Ba2+ but to a lesser extent than Mg2+. Human NIPA1 mediates Mg2+ uptake when expressed in Xenopus oocytes (Goytain et al. 2007). The other NIPA members are included as candidates based on NIPA1 function.

Literature References
PubMed ID Title Journal Year
17166836 NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter

Goytain, A, Hines, RM, El-Husseini, A, Quamme, GA

J. Biol. Chem. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
magnesium ion transmembrane transporter activity of NIPAs [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!