Reactome | Clathrin-mediated endocytosis of DT:HBEGF:CD9

Clathrin-mediated endocytosis of DT:HBEGF:CD9

Stable Identifier

R-HSA-5336422

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Related Species

Corynephage beta

Compartment

clathrin-coated endocytic vesicle membrane, plasma membrane

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Clathrin-mediated endocytosis of DT:HBEGF:CD9

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The complex of diphtheria toxin (DT A:B) and target cell surface proteins HBEGF and CD9 is taken up by endocytosis into a clathrin-coated vesicle (Moya et al. 1985; Murphy 2011).

Literature References

PubMed ID	Title	Journal	Year
22069710	Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process Murphy, JR	Toxins (Basel)	2011
2862151	Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin Louvard, D, Dautry-Varsat, A, Goud, B, Moya, M, Boquet, P	J. Cell Biol.	1985

Participants

Input

DT:HBEGF:CD9 [plasma membrane] (Homo sapiens)

Output

DT:HBEGF:CD9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Participates

as an event of

Uptake and function of diphtheria toxin (Homo sapiens)

Disease

Name	Identifier	Synonyms
diphtheria	DOID:11405	corynebacterium infection

Authored

D'Eustachio, P (2014-03-04)

Reviewed

Liu, S (2014-11-18)

Created

D'Eustachio, P (2014-03-02)

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